{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:11:48Z","timestamp":1791893508992,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,15]],"date-time":"2007-09-15T00:00:00Z","timestamp":1189814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002\u2003<\/jats:bold> It has been recently demonstrated that traumatic brain injury (TBI)\u2010mediated hypopituitarism could be more frequent than previously known. However, most of the previous data were obtained from retrospective studies, and the natural history of the hypopituitarism due to TBI is still unclear. So far no study has been reported in which the pituitary function of the same patients has been investigated more than 1\u00a0year after TBI. Therefore, we report the results of 3\u00a0years prospective follow\u2010up of anterior pituitary function in patients with mild, moderate and severe TBI.<\/jats:p><jats:p><jats:bold>Patients and design\u2002\u2003<\/jats:bold> Thirty patients (25 males, 5 females; age 37\u00b72\u00a0\u00b1\u00a02\u00b74\u00a0years) with TBI were included in the study. Pituitary function was evaluated at 1 and 3\u00a0years after TBI.<\/jats:p><jats:p><jats:bold>Results\u2002\u2003<\/jats:bold> After individual evaluation of GH deficiency from 1\u00a0year to 3\u00a0years after TBI, 7 of 13 (53\u00b78%) GH\u2010deficient patients at 1st year recovered after 3\u00a0years of TBI, and GH deficiency detected at 3\u00a0years in one patient was new onset. Additionally, five of six (83\u00b73%) ACTH\u2010deficient patients at 1st year recovered after 3\u00a0years of TBI, and ACTH deficiency detected at 3\u00a0years in one patient was new onset.<\/jats:p><jats:p><jats:bold>Conclusions\u2002\u2003<\/jats:bold> GH deficiency is the most common pituitary deficit 1 and 3\u00a0years after TBI. In patients with mild and moderate TBI, pituitary function improves over time in a considerable number of patients, but it may also worsen rarely over the 3\u2010year period. In patients with severe TBI, ACTH and GH deficiencies at 1st year evaluation persist at 3rd year.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03070.x","type":"journal-article","created":{"date-parts":[[2007,10,29]],"date-time":"2007-10-29T08:28:10Z","timestamp":1193646490000},"page":"573-579","source":"Crossref","is-referenced-by-count":91,"title":["Three years prospective investigation of anterior pituitary function after traumatic brain injury: a pilot study"],"prefix":"10.1111","volume":"68","author":[{"given":"Fatih","family":"Tanriverdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Ulutabanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kursad","family":"Unluhizarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Selcuklu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe F.","family":"Casanueva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahrettin","family":"Kelestimur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638289809166108"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.4.6506"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.5.0743"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.6.2752"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02250.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02094.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.042"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0504"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02071"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2476"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb00946.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)85043-5"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-4-773"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02755-0"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02737.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/0897715041269713"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0511"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01472.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350027"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.1.285"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.10.3713"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1300475"},{"key":"e_1_2_5_25_2","first-page":"185","article-title":"Pituitary changes in head trauma (analysis of 102 consecutive cases of head injury)","volume":"3","author":"Ceballos R.","year":"1966","journal-title":"Alabama Journal of Medical Sciences"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2007.03070.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2007.03070.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:40:56Z","timestamp":1697233256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2007.03070.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,15]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1365-2265.2007.03070.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2007.03070.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,15]]}}}