{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T22:58:01Z","timestamp":1772578681629,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,19]],"date-time":"2007-09-19T00:00:00Z","timestamp":1190160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2003<\/jats:bold> There has been a rapid shift from open to laparoscopic approaches in adrenal surgery, but the safety and efficacy of bilateral laparoscopic adrenalectomy (BLA) in patients with corticotrophin (ACTH)\u2010dependent Cushing's syndrome continues to be defined.<\/jats:p><jats:p><jats:bold>Objective\u2003<\/jats:bold> Review outcomes in the largest series of patients reported to date undergoing BLA for ACTH\u2010dependent Cushing's syndrome.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> Retrospective review study.<\/jats:p><jats:p><jats:bold>Patients\u2003<\/jats:bold> Between January of 1995 and October of 2006, BLA was attempted in 68 patients with ACTH\u2010dependent Cushing's syndrome (26 ectopic ACTH syndrome; 42 persistent pituitary\u2010dependent Cushing's syndrome following pituitary surgery).<\/jats:p><jats:p><jats:bold>Measurements\u2003<\/jats:bold> Review of peri\u2010operative morbidity and mortality, biochemical parameters and patient\u2010reported symptom response from chart review and mailed questionnaire.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> BLA was successfully completed in 59 of 68 patients (87%); nine (13%) required conversion to open adrenalectomy (OA). Intra\u2010operative complications occurred in three patients (4\u00b74%) (two BLA, one OA), and non\u2010operative complications occurred in 11 (16%) patients (eight BLA, three OA). There were no peri\u2010operative deaths. Median hospitalization was 5\u00b75\u00a0days (range, 3\u201328) and 11\u00b79\u00a0days (range, 4\u201329) for the BLA and OA groups, respectively. In patients with follow\u2010up data available, all achieved biochemical resolution and at least partial clinical resolution of signs and symptoms associated with hypercortisolism. Resolution of hypertension, diabetes and obesity was achieved in 64%, 29% and 35% of patients carrying those diagnoses prior to surgery, respectively.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> This study further supports the role of BLA as an effective treatment option for patients with ACTH\u2010dependent Cushing's syndrome.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03082.x","type":"journal-article","created":{"date-parts":[[2007,9,22]],"date-time":"2007-09-22T01:54:04Z","timestamp":1190426044000},"page":"513-519","source":"Crossref","is-referenced-by-count":77,"title":["Bilateral laparoscopic adrenalectomy for corticotrophin\u2013dependent Cushing's syndrome: a review of the Mayo Clinic experience"],"prefix":"10.1111","volume":"68","author":[{"given":"John T.","family":"Chow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey 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