{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:17:18Z","timestamp":1772734638964,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,9,29]],"date-time":"2007-09-29T00:00:00Z","timestamp":1191024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2003<\/jats:bold> The prevalence of chronic unexplained anaemia was analysed in patients with autoimmune thyroid disease (ATD).<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> The presence of chronic unexplained anaemia, defined as anaemia not related to evident or occult bleeding and\/or to erythropoietic disorders, was retrospectively assessed and compared in patients with nonautoimmune thyroid disease (NATD) and in patients with ATD.<\/jats:p><jats:p><jats:bold>Subjects and measurements\u2003<\/jats:bold> Biochemical and morphological parameters of anaemia were investigated and characterized in 1643 consecutive Caucasian outpatients with thyroid disease. In 991 patients, thyroid disease had a nonautoimmune origin. ATD was diagnosed in 652 patients (71 had Graves\u2019 disease and 581 had Hashimoto's thyroiditis and its variants). In 145 patients ATD was associated with other autoimmune disorders.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The presence of chronic unexplained anaemia was diagnosed in 123 patients (7\u00b75%). Forty\u2010eight had a thalassaemic trait, representing 2\u00b79% of the whole sample. A true chronic unexplained anaemia was recorded in 75\/1643 (4\u00b76%). The occurrence of unexplained anaemia was similar in patients with NATD (1\u00b79%) and in those with isolated ATD (2\u00b796%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0NS) but increased in patients with ATD and autoimmune related disorders (ARD) compared to patients with isolated ATD and\/or with NATD (28\u00b73%; both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001; RR\u00a0=\u00a09\u00b756 and 14\u00b775, respectively). Chronic unexplained anaemia was virtually absent in hyperthyroid patients and was more prevalent in hypothyroid than in euthyroid patients with ATD (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b70047; RR\u00a0=\u00a02\u00b7104).<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> These results indicate that the increased frequency of chronic anaemia in patients with ATD is essentially due to the presence of concomitant autoimmune gastrointestinal diseases.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03091.x","type":"journal-article","created":{"date-parts":[[2007,9,30]],"date-time":"2007-09-30T10:20:35Z","timestamp":1191147635000},"page":"640-645","source":"Crossref","is-referenced-by-count":34,"title":["Chronic unexplained anaemia in isolated autoimmune thyroid disease or associated with autoimmune related disorders"],"prefix":"10.1111","volume":"68","author":[{"given":"Rosanna","family":"Sibilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giulia","family":"Santaguida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Virili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucilla","family":"Gargano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Nardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Della","family":"Guardia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Viceconti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Franchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Centanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00263-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0146"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1812"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52116.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00949.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2006.05.006"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-40-2-211"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31963-0"},{"key":"e_1_2_6_10_2","first-page":"101","article-title":"The haematology of hypothyroidism","volume":"45","author":"Horton L.","year":"1976","journal-title":"Quarterly Journal of Medicine"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/archinte.1982.00340210057014","article-title":"Clinical and subclinical thyroid disorders associated with pernicious anemia","volume":"142","author":"Carmel R.","year":"1982","journal-title":"Archives of Internal Medicine"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1212126"},{"key":"e_1_2_6_13_2","first-page":"134","article-title":"Autoimmune phenomena in pernicious anaemia. 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