{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:47:53Z","timestamp":1790264873312,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T00:00:00Z","timestamp":1191801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    A survey of physicians\u2019 practice relating to radioiodine administration for hyperthyroidism was carried out in the UK over 15\u00a0years ago and showed wide variations in patient management. This led to the development of national guidelines for the use of radioiodine in hyperthyroidism. As there have been significant advances in the field since that survey, we carried out another survey to study the prevalent practices relating to radioiodine therapy for benign thyroid disorders across the UK.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Subjects and methods\u2002<\/jats:bold>\n                    We mailed 698 UK consultant endocrinologists a questionnaire on radioiodine treatment based on three patient scenarios: hyperthyroid Graves\u2019 disease, subclinical hyperthyroidism and nontoxic goitre.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    The response rate was 40%. For the scenario of an initial presentation of Graves\u2019 disease, 80%, 19% and 0\u00b74% of respondents preferred thionamide, radioiodine or thyroidectomy, respectively. There were inconsistencies in respondents\u2019 recommendations on radioiodine dose, the use of pre\u2010 and post\u2010radioiodine supplementary treatments, timing of a repeat dose, and the use of radioiodine in thyroid eye disease. For the case of subclinical hyperthyroidism, one\u2010third of respondents would generally initiate treatment. The majority were more likely to treat subclinical hyperthyroidism in the presence of paroxysmal atrial fibrillation or osteoporosis. If a decision were made to treat subclinical hyperthyroidism, 63%, 35%, 1% and 0\u00b74% would recommend radioiodine, thionamide, beta\u2010blocker and thyroidectomy, respectively. For the scenario of nontoxic goitre, 62%, 21%, 13% and 5% favoured observation, thyroidectomy, radioiodine and thyroxine, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions\u2002<\/jats:bold>\n                    There remain significant differences in several aspects of clinical practice relating to the use of radioiodine treatment for benign thyroid disorders in the UK.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03097.x","type":"journal-article","created":{"date-parts":[[2007,10,8]],"date-time":"2007-10-08T13:55:10Z","timestamp":1191851710000},"page":"814-820","source":"Crossref","is-referenced-by-count":57,"title":["Radioiodine treatment for benign thyroid disorders: results of a nationwide survey of UK endocrinologists"],"prefix":"10.1111","volume":"68","author":[{"given":"Bijay","family":"Vaidya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon H. 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