{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:12:02Z","timestamp":1761894722754},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T00:00:00Z","timestamp":1195430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> The success of an amylin analogue in weight loss trials has generated interest in amylin as a physiological satiety signal. Little is known about how plasma amylin responds to macronutrients. This study examined the effects of a high\u2010carbohydrate meal (CHO), a high\u2010fat meal (FAT) or a continued fast (FAST) on amylin concentrations and correlations among other satiety hormones and measures of appetite.<\/jats:p><jats:p><jats:bold>Design\/patients\u2002<\/jats:bold> In a randomized, crossover design, 10 healthy males consumed a meal high in carbohydrate or fat or continued fasted.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Blood samples and subjective hunger scores were obtained at baseline and 30, 90 and 210\u00a0min postprandial.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> After CHO, amylin, insulin and C\u2010peptide were greater and des\u2010acyl ghrelin lower compared to FAT (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7001). Area under the curve (AUC) was greater for amylin and insulin and lower for des\u2010acyl ghrelin following CHO. Subjective satiety and fullness were higher for CHO and FAT than FAST at 30 and 90\u00a0min but only for CHO at 210\u00a0min (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b701). Hunger and desire to eat were lower for CHO and FAT than FAST at 30 and 90\u00a0min but only for CHO at 210\u00a0min (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00\u00b7005). Amylin was negatively correlated to hunger, desire to eat, and nausea and positively related to satiety and insulin. Des\u2010acyl ghrelin was negatively associated with C\u2010peptide, insulin and GLP\u20101 and satiety.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> CHO enhances amylin and suppresses des\u2010acyl ghrelin to a greater extent than FAT in healthy men. The mechanisms responsible for these changes and their implications in the physiology of satiety remain to be elucidated.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03129.x","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T07:51:57Z","timestamp":1210924317000},"page":"890-897","source":"Crossref","is-referenced-by-count":17,"title":["Differential responses of circulating amylin to high\u2010fat <i> vs.<\/i> high\u2010carbohydrate meal in healthy men"],"prefix":"10.1111","volume":"68","author":[{"given":"Lindsay K.","family":"Eller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc J.","family":"Poulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raylene 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