{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:11:28Z","timestamp":1790377888705,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory.<\/jats:p><jats:p><jats:bold>Context\u2002<\/jats:bold> PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] are unanimous recognized. We aimed to assess in women with suspected PCOS whether the application of the three diagnostic criteria differently characterizes the metabolic profile and insulin sensitivity.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Retrospective study in a cohort of women admitted to our Outpatient Clinic for suspected PCOS.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Two hundred and four women with suspected PCOS in comparison to a group of normal, age\u2010matched Sicilian women (<jats:italic>N<\/jats:italic>\u00a0=\u00a034) without signs of metabolic syndrome.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> We evaluated hyperandrogenaemia and clinical hyperandrogenism, ovarian morphology, hypothalamo\u2013hypophyseal axis and metabolic syndrome parameters. An oral glucose tolerance test (OGTT; 75\u00a0g glucose) measured areas under the curve (AUC) for insulin, C peptide and homeostasis model assessment of insulin\u2010resistance (HOMA\u2010IR) were performed.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The prevalence of PCOS was 51% according to NIH, 83% to ROT and 70\u00b76% to AES, and only 100 patients were qualified simultaneously under these three criteria. The prevalence of the metabolic syndrome in PCOS women was 26\u00b792% (NIH), 21\u00b777% (ROT) and 23\u00b761% (AES), respectively. In comparison to healthy women, PCOS women showed increased fasting insulinaemia (PCOS\/ROT: <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7028; PCOS\/NIH: <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007; PCOS\/EAS: <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7023), 120\u00a0min insulin after OGTT insulinaemia (for the three criteria: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), AUC<jats:sub>2h<\/jats:sub> insulin (for the three criteria: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and AUC<jats:sub>2h<\/jats:sub> C peptide (for the three criteria: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our study highlights the fact that regardless of the diagnostic criteria used, evaluation of the metabolic parameters and insulin sensitivity is important for a correct diagnosis of PCOS and a therapeutic approach.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2007.03145.x","type":"journal-article","created":{"date-parts":[[2008,6,17]],"date-time":"2008-06-17T13:20:22Z","timestamp":1213708822000},"page":"52-60","source":"Crossref","is-referenced-by-count":37,"title":["The evaluation of metabolic parameters and insulin sensitivity for a more robust diagnosis of the polycystic ovary syndrome"],"prefix":"10.1111","volume":"69","author":[{"given":"Marco Calogero","family":"Amato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Galluzzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Finocchiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Criscimanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_5_2_2","unstructured":"Chereau A.(1844)M\u00e9moires pour servir a` l\u2019\u00e9tude des maladies des ovaires.Fortin Masson Cie Paris."},{"key":"e_1_2_5_3_2","first-page":"246","volume-title":"A Manual of Pathological Anatomy","author":"Rokitansky C.","year":"1855"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30642-6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/09513598709023610"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0004"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108400"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.9.1165"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:30:1:13"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0628"},{"key":"e_1_2_5_12_2","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadski J.K.","year":"1992"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"e_1_2_5_16_2","unstructured":"The IDF consensus worldwide definition of the metabolic syndrome. Available fromhttp:\/\/www.idf.org\/webdata\/docs\/IDF_Metasyndrome_definition.pdf(Accessed 07 June 2005)."},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_5_18_2","first-page":"189","article-title":"Assessment of insulin sensitivity\/resistance in epidemiological studies","volume":"37","author":"Radikova Z.","year":"2003","journal-title":"Endocrine Regulations"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590500170049"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2757"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.774"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.4.0374"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.2.644"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0015"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-6-1027"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2490"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345554"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1045"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(03)00104-5"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02058"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02290"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0870"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.20671"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2007.03145.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2007.03145.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:35:09Z","timestamp":1697229309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2007.03145.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,28]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1111\/j.1365-2265.2007.03145.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2007.03145.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,28]]}}}