{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:02:23Z","timestamp":1790262143042,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T00:00:00Z","timestamp":1200873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background\u2002<\/jats:bold>\n                    Bisphosphonate use in adult patients has been linked to osteonecrosis of the jaw (ONJ). This complication has not been systematically assessed in a paediatric population receiving bisphosphonates.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    To assess our cohort of paediatric patients treated with intravenous bisphosphonate for occurrence of ONJ.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    Observational study at a tertiary children's hospital.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients\u2002<\/jats:bold>\n                    A total of 42 paediatric patients with osteoporosis who received bisphosphonate infusions for a mean of 6\u00b75\u00a0years (SD 2\u00b77\u00a0years) were assessed clinically and radiographically for possible ONJ. Among 42, 37 patients had received disodium pamidronate 1\u00a0mg\/kg\/dose at a mean cumulative dose of 19\u00b78\u00a0mg\/kg and zoledronic acid (ZA) 0\u00b705\u00a0mg\/kg\/dose at a mean cumulative dose of 0\u00b749\u00a0mg\/kg; four had received ZA and one received pamidronate alone. Invasive dental treatment during bisphosphonate treatment, a known risk factor for osteonecrosis, was specifically assessed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    In all patients assessed, including 11 who had invasive dental treatment, there were no cases of osteonecrosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    ONJ has so far not been demonstrated in this patient group.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03189.x","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T03:51:57Z","timestamp":1210909917000},"page":"863-867","source":"Crossref","is-referenced-by-count":55,"title":["Bisphosphonate\u2010associated osteonecrosis of the jaw: does it occur in children?"],"prefix":"10.1111","volume":"68","author":[{"given":"J. J.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Zacharin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2004.17.11.1511"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.375"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114459"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650101008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555852"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119668"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050213"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00083.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.036590"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16051-0"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090521"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-10-200605160-00009"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.0707onj"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.04.196"},{"key":"e_1_2_5_18_2","first-page":"801","article-title":"Bisphosphonates and osteonecrosis of the jaw","volume":"35","author":"Sambrook P.","year":"2006","journal-title":"Australian Family Physician"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2005.0108"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810013391402"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.5.1846"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.5.356"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2002.15.2.163"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200507073530120"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200507073530120"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067312"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320908"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1138\/20060224"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2006.06.005"},{"key":"e_1_2_5_32_2","doi-asserted-by":"crossref","unstructured":"Simm P.J. 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