{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:51:39Z","timestamp":1790041899364,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,25]],"date-time":"2008-01-25T00:00:00Z","timestamp":1201219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> GH is usually the first pituitary hormone to be affected following a pathological insult to the pituitary; however, data on the prevalence of GH deficiency in patients with nonsecreting pituitary microadenomas and normal serum IGF\u20101 levels are scarce. This study aims to evaluate the prevalence of GH and other anterior pituitary hormone deficiencies, and to determine whether microadenomas <jats:italic>per se<\/jats:italic> could be associated with reduced GH response rates to GHRH\u2013arginine stimulation.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Analytical, retrospective, two\u2010site case\u2010control study.<\/jats:p><jats:p><jats:bold>Patients and methods\u2002<\/jats:bold> Thirty\u2010eight patients with nonsecreting pituitary microadenomas (mean size 4\u00b72\u00a0mm) and normal serum IGF\u20101 levels were studied. Anterior pituitary function testing, including the GHRH\u2013arginine test to examine GH reserve, was performed in all patients. Serum IGF\u20101 levels and peak GH levels in the patients that passed the GHRH\u2013arginine test were compared with 22 age\u2010 and BMI\u2010matched healthy controls.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Nineteen patients (50%) failed the GHRH\u2013arginine test and had higher body mass index (BMI) than those that passed the GHRH\u2013arginine test and healthy controls. Peak GH levels in patients that passed the GHRH\u2013arginine test were lower compared to healthy controls and 19 patients (50%) had at least one other pituitary hormone deficit. A negative correlation (<jats:italic>r<\/jats:italic>\u00a0=<jats:italic>\u00a0\u2013<\/jats:italic>0\u00b742, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) between peak GH levels and BMI was identified, but no correlations were found between peak GH and serum IGF\u20101 levels.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our data demonstrated that a substantial number of patients with nonsecreting pituitary microadenomas failed the GHRH\u2013arginine test despite normal serum IGF\u20101 levels, and had at least one other pituitary hormone deficiency, suggesting that nonsecreting microadenomas may not be clinically harmless. We therefore recommend long\u2010term follow\u2010up with periodic basal pituitary function testing, and to consider dynamic pituitary testing should clinical symptoms arise in these patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03201.x","type":"journal-article","created":{"date-parts":[[2008,1,25]],"date-time":"2008-01-25T10:36:32Z","timestamp":1201257392000},"page":"292-298","source":"Crossref","is-referenced-by-count":46,"title":["Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF\u20101 levels"],"prefix":"10.1111","volume":"69","author":[{"given":"Kevin C. 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