{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:32:00Z","timestamp":1767007920032},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T00:00:00Z","timestamp":1218499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objectives\u2002<\/jats:bold> In acromegalic patients, cardiovascular and metabolic comorbidities contribute to enhance mortality. Available data on the lipoprotein profile of these patients are controversial. Our aim was to characterize the lipoprotein profile and emergent biomarkers of cardiovascular disease in active acromegalic patients in comparison with sex\u2010 and age\u2010matched healthy controls.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Eighteen patients with active acromegaly and 18 controls were studied.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Glucose levels, hormonal status, lipoprotein profile and C reactive protein (CRP) were evaluated by standardized methods. Cholesteryl ester transfer protein (CETP) and lipoprotein\u2010associated phospholipase A<jats:sub>2 <\/jats:sub>(Lp\u2010PLA<jats:sub>2<\/jats:sub>) were measured by radiometric techniques, endothelin\u20101 and vascular cell adhesion molecule (VCAM)\u20101 by enzyme\u2010linked immunosorbent assay, and leucocytes CD18, CD49d and CD54 by flow cytometry.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> After adjusting for body mass index (BMI), acromegalic patients presented a more atherogenic lipoprotein profile, consisting of higher levels of triglycerides and apolipoprotein B and alterations in the ratios which estimate insulin resistance and atherogenic risk. CETP activity was significantly increased in acromegalic patients as compared to controls (168\u00a0\u00b1\u00a017 <jats:italic>vs<\/jats:italic>. 141\u00a0\u00b1\u00a030%\u00a0per ml\u00a0h, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Endothelin\u20101 levels evidenced an increase in the patients\u2019 group (0\u00b79\u00a0\u00b1\u00a00\u00b72 <jats:italic>vs<\/jats:italic>. 0\u00b77\u00a0\u00b1\u00a00\u00b72\u00a0ng\/l, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701) and showed positive and significant correlations with GH, IGF\u20101 and IGFBP\u20103 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b745, 0\u00b742 and 0\u00b744, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701 for all of them; with BMI as a fixed variable). Lymphocytes from acromegalic patients showed increased CD49d content (282\u00a0\u00b1\u00a059 <jats:italic>vs<\/jats:italic>. 246\u00a0\u00b1\u00a048 arbitrary units, respectively; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Taken together, the alterations described seem to contribute to constituting a state of higher propensity for the development of atherosclerotic cardiovascular disease, which adds to the presence of specific cardiomyopathy.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03323.x","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T08:27:12Z","timestamp":1218529632000},"page":"88-95","source":"Crossref","is-referenced-by-count":32,"title":["Alterations in biomarkers of cardiovascular disease (CVD) in active acromegaly"],"prefix":"10.1111","volume":"70","author":[{"given":"L.","family":"Boero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Manavela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"G\u00f3mez Rosso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Insua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Berardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Fornari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Brites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,12,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1994.tb03789.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2857"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02036"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01218.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.193"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1046\/j.1365-2265.2001.01326.x","article-title":"The atherogenic plasma remnant\u2010like particle cholesterol concentration is increased in the fasting and postprandial state in active acromegalic patients","volume":"55","author":"Twickler T.B.","year":"2001","journal-title":"Clinical Endocrinology"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(96)06015-7"},{"key":"e_1_2_6_9_2","first-page":"358","article-title":"The incidence and pathogenesis of hyperlipidaemia in 16 consecutive acromegalic patients","volume":"100","author":"Takeda R.","year":"1982","journal-title":"Acta Endocrinologica (Copenh)"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00433-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1013498"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00426-8"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00021"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01256.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8364"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.2.526"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(84)90153-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/clinchem\/28.6.1379","article-title":"Dextran sulfate\u2010Mg2+ precipitation procedure for quantitation of high\u2010density\u2010lipoprotein cholesterol","volume":"28","author":"Warnick G.R.","year":"1982","journal-title":"Clinical Chemistry"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.13.6.815"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)91778-3"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0897.2002.01128.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-10-200311180-00007"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1210974"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112422"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023321421760"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199506000-00007"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.03.085"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.3.936"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.2.799"},{"key":"e_1_2_6_31_2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1046\/j.1365-2265.2003.01780.x","article-title":"Growth hormone, acromegaly, and heart failure: an intricate triangulation","volume":"59","author":"Sacc\u00e0 L.","year":"2003","journal-title":"Clinical Endocrinology"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(93)90031-E"},{"key":"e_1_2_6_33_2","first-page":"121","article-title":"Role of endothelin\u20101 in genesis of coronary artery disease","volume":"57","author":"Sainani G.S.","year":"2005","journal-title":"Indian Heart Journal"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350799"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(99)00117-7"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1139\/y05-002"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2001.00882.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000095980.43859.59"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.10.63"},{"key":"e_1_2_6_40_2","first-page":"409","article-title":"The acute phase reaction syndrome: the acute phase reactants","volume":"45","author":"Jakab L.","year":"1998","journal-title":"Acta Microbiologica Immunologica Hungarica"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1999.0454"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.066"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986706777935221"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2008.03323.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2008.03323.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T15:04:57Z","timestamp":1697209497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2008.03323.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,30]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1111\/j.1365-2265.2008.03323.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03323.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,30]]}}}