{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:39:55Z","timestamp":1779889195254,"version":"3.53.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,19]],"date-time":"2009-01-19T00:00:00Z","timestamp":1232323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>No data on results of repeated transsphenoidal surgery via the endoscopic technique for patients with persistent or recurrent Cushing's disease are available.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold>We retrospectively evaluated the remission rates and complications of repeated transsphenoidal surgery via the endoscopic technique in 14 patients with persistent (<jats:italic>N<\/jats:italic>\u00a0=\u00a06) or recurrent (<jats:italic>N<\/jats:italic>\u00a0=\u00a08) Cushing's disease treated in our centre between 1999 and 2007.<\/jats:p><jats:p><jats:bold>Main outcomes\u2002<\/jats:bold>Remission was defined as the disappearance of symptoms of hypercortisolism with basal plasma cortisol level\u00a0\u2264\u00a050\u00a0nmol\/l 24\u201348\u00a0h after glucocorticoid withdrawal and\/or suppression of plasma cortisol level\u00a0\u2264\u00a050\u00a0nmol\/l after 1\u00a0mg dexamethasone overnight within the first 3\u00a0months after transsphenoidal surgery.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>With repeated endoscopic transsphenoidal surgery a remission rate of 10\/14 (71%) was achieved. No patient had a relapse during a median follow\u2010up of 24\u00a0months. Cerebrospinal fluid leakage was the most frequent complication (6 patients) and 11 patients required hormonal substitution after surgery. The success of repeated transsphenoidal surgery could not be predicted by visualization of an adenoma on MRI before first or second surgery, histopathological confirmation of an ACTH secreting adenoma after first or second surgery, treatment with cortisol lowering agents before first or second surgery, the operation technique used during the first surgery, persistent<jats:italic>vs.<\/jats:italic>recurrent disease after the first surgery, age, gender and interval between the two surgeries.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold>Repeated transsphenoidal surgery via the endoscopic technique is a good treatment option for selected patients with recurrent or persistent Cushing's disease following primary pituitary surgery.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03334.x","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T10:25:57Z","timestamp":1218709557000},"page":"274-280","source":"Crossref","is-referenced-by-count":49,"title":["Repeated transsphenoidal pituitary surgery (TS) via the endoscopic technique: a good therapeutic option for recurrent or persistent Cushing's disease (CD)"],"prefix":"10.1111","volume":"70","author":[{"given":"M. A. E. M.","family":"Wagenmakers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. T.","family":"Netea\u2010Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Van Lindert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J. L. M.","family":"Timmers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Grotenhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R. M. M.","family":"Hermus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030871"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-0407-6"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02133"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200207000-00008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2007.23.3.7"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02380.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01511.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030751"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2007.23.3.10"},{"key":"e_1_2_5_11_2","doi-asserted-by":"crossref","unstructured":"Biller B.M. Grossman A.B. Stewart P.M.et\u00a0al.(2008)Treatment of ACTH\u2013dependent Cushing's syndrome: a consensus statement.Journal of Clinical Endocrinology and Metabolism.","DOI":"10.1016\/S0084-3741(08)79081-4"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9344-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.4.0678"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00353737"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80069-8"},{"key":"e_1_2_5_16_2","first-page":"991","article-title":"Laparoscopic adrenalectomy: lessons learned from an initial series of 100 patients","volume":"4","author":"Gil\u2010Cardenas A.","year":"2007","journal-title":"Surgical Endoscopy"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00578.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01187.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022308429992"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.6.1004"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1989.71.4.0520"},{"key":"e_1_2_5_22_2","first-page":"31","article-title":"Persistent and recurrent hypercortisolism after transsphenoidal surgery for Cushing's disease","volume":"65","author":"Knappe U.J.","year":"1996","journal-title":"Acta Neurochirurgica Supplementum"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2436"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1994.80.1.0037"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000215945.26764.92"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0208"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.6.1343"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8814"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-932126"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/000456329703400302"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.4.1640"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-10-738"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199109263251301"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1052019"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199908000-00041"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.87.1.0044"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688690050175229"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800560315"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-818489"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-005-0586-3"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200212000-00006"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-005-5351-3"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03012.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2008.03334.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2008.03334.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T13:41:10Z","timestamp":1738330870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2008.03334.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,19]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1111\/j.1365-2265.2008.03334.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03334.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,19]]}}}