{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:42:22Z","timestamp":1785192142585,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T00:00:00Z","timestamp":1219363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To determine the relationship between anaemia and myelofibrosis in patients with symptomatic primary hyperparathyroidism (PHPT) and to assess the effect of curative parathyroidectomy on anaemia and marrow fibrosis.<\/jats:p><jats:p><jats:bold>Design and methods\u2002<\/jats:bold>In this prospective follow\u2010up study of 28 consecutive patients with symptomatic PHPT from January 2005 to June 2006, 15 patients were diagnosed with anaemia (haemoglobin &lt; 130\u00a0g\/l in males and &lt; 120\u00a0g\/l in females), eight (53%) of whom were finally recruited for the study. Complete blood cell count, serum calcium, phosphorus, alkaline phosphatase, intact PTH and 25\u2010hydroxyvitamin D and bone marrow examination were performed both before and after parathyroidectomy in all (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) patients, but bone marrow examination after surgery was performed only in those who had marrow fibrosis at baseline (<jats:italic>n<\/jats:italic>\u00a0=\u00a06).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Anaemia was observed in 15 (53\u00b73%) of the 28 patients with symptomatic PHPT. Normocytic normochromic anaemia that is characteristic of PHPT was found in 14 (50%) patients. Eight of the 15 patients with anaemia had a bone marrow examination and marrow fibrosis was observed in six (75%). Both anaemia and marrow fibrosis improved after successful parathyroidectomy, but improvement in anaemia was significant (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b702) only in those with marrow fibrosis at baseline. Marrow fibrosis did not correlate with duration of the disease (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b717), degree of hypercalcaemia (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b753) or serum levels of intact PTH (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b760).<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Anaemia is common in patients with symptomatic PHPT, and was associated with marrow fibrosis in the majority of the patients who underwent bone biopsy. Both anaemia and marrow fibrosis improved after curative parathyroidectomy, but improvement in anaemia was noticeable only in those who had marrow fibrosis at presentation.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03346.x","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T15:24:05Z","timestamp":1219418645000},"page":"527-532","source":"Crossref","is-referenced-by-count":36,"title":["Anaemia and marrow fibrosis in patients with primary hyperparathyroidism before and after curative parathyroidectomy"],"prefix":"10.1111","volume":"70","author":[{"given":"Sanjay K.","family":"Bhadada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Ahluwalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. V.","family":"Chanukya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunanshu","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinaki","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800197405"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1934.02750160010003"},{"key":"e_1_2_6_4_2","first-page":"127","article-title":"Primary hyperparathyroidism","volume":"53","author":"Mallette L.E.","year":"1974","journal-title":"Clinical and Biochemical Features Medicine"},{"key":"e_1_2_6_5_2","first-page":"28","article-title":"Anaemia in primary hyper\u2010parathyroidism [in French]","volume":"7","author":"Bernheim J.","year":"1986","journal-title":"Nephrologie"},{"key":"e_1_2_6_6_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1001\/archinte.1977.03630170020008","article-title":"Anemia in primary hyper\u2010parathyroidism","volume":"137","author":"Boxer M.","year":"1977","journal-title":"Archives of Internal Medicine"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/089198879300600305"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb01480.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817820"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197710000-00014"},{"key":"e_1_2_6_11_2","unstructured":"World Health Organization. (1968)Nutritional anaemias: report of a WHO scientific group.World Health Organization Geneva Switzerland."},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0021-9258(18)85009-8","volume":"63","author":"Clark E.P.","year":"1925","journal-title":"Journal of Biology and Chemistry"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/ajcp\/56.1.24","article-title":"Quantifications of bone marrow reticulin\u2010a normal range","volume":"56","author":"Bauerneister D.E.","year":"1971","journal-title":"American Journal of Clinical Pathology"},{"key":"e_1_2_6_14_2","first-page":"593","article-title":"Prevalence of anaemia among school going adolescents of Chandigarh","volume":"42","author":"Basu S.","year":"2005","journal-title":"Indian Pediatrics"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051215"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5615.395"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012098651-4\/50024-9"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb02043.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.5144\/0256-4947.2005.29"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2802"},{"key":"e_1_2_6_21_2","first-page":"3","article-title":"Genomic structure, induction, and production of TNF\u2010alpha","volume":"56","author":"Spriggs D.R.","year":"1992","journal-title":"Immunology Series"},{"key":"e_1_2_6_22_2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/jbmr.5650081003","article-title":"Regulation of cytokine expression in osteoblasts by parathyroid hormone: rapid stimulation of interleukin\u20106 and leukemia inhibitory factor mRNA","volume":"10","author":"Greenfield E.M.","year":"1993","journal-title":"Journal of Bone Mineral Research"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.4049\/jimmunol.145.10.3297","article-title":"IL\u20106 is produced by osteoblasts and induces bone resorption","volume":"145","author":"Ishimi Y.","year":"1990","journal-title":"Journal of Immunology"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65698-2"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.8.1987.1987"},{"key":"e_1_2_6_26_2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1210\/endo.133.2.8393771","article-title":"Parathyroid hormone (PTH)\/PTHrelated peptide receptor messenger ribonucleic acids are widely distributed in rat tissues","volume":"133","author":"Urena P.","year":"1993","journal-title":"Endocrinology"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301213280304"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2008.03346.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2008.03346.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T12:32:52Z","timestamp":1709209972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2008.03346.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,3]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1111\/j.1365-2265.2008.03346.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03346.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,3]]}}}