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Amiodarone\u2010induced thyroid disorders are common and often present as a management challenge for endocrinologists. The pathogenesis of amiodarone\u2010induced thyroid dysfunction is complex but the inherent effects of the drug itself as well as its high iodine content appear to play a central role. The non\u2010iodinated dronedarone also exhibits anti\u2010arrhythmic properties but appears to be less toxic to the thyroid. This review describes the biochemistry of benzofuran derivatives, including their pharmacology and the physiology necessary for understanding the cellular mechanisms involved in their actions. The known effects of these compounds on thyroid action are described. Recommendations for management of amiodarone\u2010induced hypothyroidism and thyrotoxicosis are suggested. Dronedarone appears to be an alternative but less\u2010effective anti\u2010arrhythmic agent and it does not have adverse effects on thyroid function. It may have a future role as an alternative agent in patients being considered for amiodarone therapy especially those at high risk of developing thyroid dysfunction but not in severe heart failure.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03350.x","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T15:24:29Z","timestamp":1219418669000},"page":"2-13","source":"Crossref","is-referenced-by-count":57,"title":["Benzofuran derivatives and the thyroid"],"prefix":"10.1111","volume":"70","author":[{"given":"T. S.","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P. 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