{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:22Z","timestamp":1787014462874,"version":"build-2736575974"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T00:00:00Z","timestamp":1218758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective\u2002<\/jats:bold>\n                    Pharmacological treatment with dopaminergic agonists (DA) is the treatment of choice for prolactinomas. Surgical and radiation treatment is also indicated in certain situations. We describe our 12\u2010year experience in treating prolactinomas with the Leksell gamma knife (LGK).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design\u2002<\/jats:bold>\n                    We followed 35 prolactinoma patients (25\u00b77% microprolactinomas, 74\u00b73% macroprolactinomas) treated with LGK irradiation. The mean follow\u2010up period was 75\u00b75\u00a0months. Prior to LGK irradiation, patients were treated with DA and 10 of them (28\u00b76%) underwent neurosurgery. Indications for LGK irradiation were: DA intolerance (31\u00b74%), DA resistance (45\u00b77%) and efforts to reduce the DA dose or shorten the period of administration (22\u00b79%). Pituitary function was monitored regularly at 6\u2010month intervals. The central radiation dose range was 40\u201380 Gy (median 70 Gy), and the minimal peripheral dose was 20\u201349 Gy (median 34 Gy).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results\u2002<\/jats:bold>\n                    Normoprolactinaemia was achieved in 37\u00b71% of the patients who discontinued DA and in 42\u00b79% of patients who continued DA treatment after LGK irradiation. The median time to prolactin normalization after discontinuation of DA was 96\u00a0months. No relapse was seen in any patient. After LGK irradiation, the prolactinoma stopped growing or decreased in size in all but one patient (97\u00b71%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion\u2002<\/jats:bold>\n                    LGK treatment resulted in normoprolactinaemia in 80\u00b70% of the patients, all of whom had failed pharmacological treatment due to DA resistance or intolerance. After achieving normoprolactinaemia, no relapse of hyperprolactinaemia was observed in any patient. The size of the adenoma decreased even in those patients in whom it was not changed by previous DA treatment.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03384.x","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T06:23:30Z","timestamp":1218781410000},"page":"732-741","source":"Crossref","is-referenced-by-count":52,"title":["Use of the Leksell gamma knife in the treatment of prolactinoma 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