{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:58:16Z","timestamp":1791262696601,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T00:00:00Z","timestamp":1218758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Rett syndrome is a progressive neurological disorder affecting almost exclusively females after age 6\u00a0months and characterised by acquired microcephaly, psychomotor retardation, growth failure, purposeless hand movements, autistic\u2010like behaviour and wide\u2010based and stiff legged gait. Leptin and adiponectin, peptides secreted by adipose tissue, are involved in the regulation of body weight and energy expenditure.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> We investigated in patients with Rett syndrome the variations of plasma leptin and adiponectin and their relation over a 2\u2010year period. Sixteen female patients, mean age at the basal time 9\u00b74\u00a0\u00b1\u00a04\u00b73\u00a0years, with classical Rett syndrome were enrolled. Controls were 16 healthy female subjects, mean age at the basal time 9\u00b79\u00a0\u00b1\u00a03\u00b74\u00a0years.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Blood samples were withdrawn in the morning at the baseline, 12\u00a0months after and 24\u00a0months after; plasma leptin and adiponectin concentrations were detected by ELISA.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In patients, leptin concentrations significantly increased, while adiponectin concentrations significantly decreased. Both leptin and adiponectin values were significantly higher than those found in controls at each time. Leptin significantly correlated with adiponectin in patients, while there was not a significant correlation in controls.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Since all patients were not obese, we might hypothesize that in Rett syndrome leptin and adiponectin might participate to clinical manifestations other than weight balance.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03386.x","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T10:24:15Z","timestamp":1218795855000},"page":"706-709","source":"Crossref","is-referenced-by-count":39,"title":["Long\u2010term plasma levels of leptin and adiponectin in Rett syndrome"],"prefix":"10.1111","volume":"70","author":[{"given":"P.","family":"Blardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"De Lalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"D\u2019Ambrogio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vonella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ceccatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Auteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hayek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi198"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389400900319"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/jada.2003.50026"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00050-2"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.33549\/physiolres.930280","article-title":"Leptin levels in obese children: effects of gender, weight reduction and androgens","volume":"52","author":"Pilcova R.","year":"2003","journal-title":"Physiological Research"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.10.061"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.33549\/physiolres.930600","article-title":"Adiponectin, an adipocyte\u2010derived protein","volume":"54","author":"Nedvidkova J.","year":"2005","journal-title":"Physiological Research"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0255"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.046540"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2038-9"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.9.2904"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/frne.2000.0197"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis","volume":"68","author":"Fantuzzi G.","year":"2000","journal-title":"Journal of Leukocyte Biology"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1210\/jcem.83.1.4610","article-title":"Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion","volume":"83","author":"Bornstein S.R.","year":"1998","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0303"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2005.02.003"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2006.03.001"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcfm.2005.08.013"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1237"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815789"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119532"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.12.030"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2008.03386.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2008.03386.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T14:41:46Z","timestamp":1697208106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2008.03386.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,31]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1111\/j.1365-2265.2008.03386.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2008.03386.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,31]]}}}