{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:31:04Z","timestamp":1782603064922,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T00:00:00Z","timestamp":1219276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Multiple diagnostic modalities may be needed to establish the source of excessive androgen production in women. The role of selective venous catheterization in this process has not been established fully.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A study of hyperandrogenaemic subjects and literature review.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Four hyperandrogenaemic women and an additional 132 previously reported cases with available testing data and a pathological diagnosis were evaluated.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Serum androgens, diagnostic imaging and ovarian venous effluent sampling. Criteria to distinguish ovarian tumours from other ovarian conditions and to localize the lesion(s) were evaluated.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Basal peripheral testosterone levels \u2265\u00a04\u00b751\u00a0nmol\/l (\u2265\u00a0130\u00a0ng\/dl) discriminated ovarian tumours from benign causes of hyperandrogenism (sensitivity: 93\u00b78%, 95%\u00a0CI 85\u00b70\u201398\u00b72; specificity: 77\u00b78%, 95%\u00a0CI 66\u00b74\u201386\u00b77). Single lesions produced higher ipsilateral testosterone concentrations (612\u00b76\u00a0\u00b1\u00a0162\u00b70\u00a0nmol\/l; 17\u00a0653\u00a0\u00b1\u00a04670\u00a0ng\/dl) compared to contralateral values (26\u00b74\u00a0\u00b1\u00a05\u00b72\u00a0nmol\/l; 761\u00a0\u00b1\u00a0150\u00a0ng\/dl). In women with peripheral testosterone \u2265\u00a04\u00b751\u00a0nmol\/l, a right\u2010to\u2010left (R:L) ovarian testosterone ratio \u2265\u00a01\u00b744 correctly identified all 18 women with right\u2010sided tumours and misclassified two with bilateral lesions; 12 out of 14 women with left\u2010sided or bilateral lesions had a lower R:L value. When this criterion was combined with a left\u2010to\u2010right (L:R) ovarian testosterone effluent ratio of &gt;\u00a015 to identify left\u2010sided tumours, overall 66% of women were correctly categorized.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Peripheral testosterone concentrations identified ovarian androgen\u2010producing tumours, and venous sampling could correctly localize 66% of these, suggesting a role for sampling when imaging studies are not revealing.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03389.x","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T10:57:42Z","timestamp":1219316262000},"page":"606-614","source":"Crossref","is-referenced-by-count":54,"title":["Selective venous sampling for androgen\u2010producing ovarian pathology"],"prefix":"10.1111","volume":"70","author":[{"given":"Eric D.","family":"Levens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W.","family":"Whitcomb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Csokmay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynnette K.","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,3,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0015-0282(16)49871-7","article-title":"Diagnostic considerations in virilization: iodomethyl\u2010norcholesterol scanning in the localization of androgen secreting tumors","volume":"46","author":"Taylor L.","year":"1986","journal-title":"Fertility and 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