{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:45:25Z","timestamp":1794469525228,"version":"4.9.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T00:00:00Z","timestamp":1220313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Vitamin D is essential for skeletal health and prolonged deficiency results in infantile rickets and adult osteomalacia. The aim of this study is to determine the vitamin D status in pregnancy and to evaluate the effects of daily and of single\u2010dose vitamin D supplementation.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> A prospective randomized study at St Mary's Hospital London.<\/jats:p><jats:p><jats:bold>Patients<\/jats:bold> A total of 180 women (Indian Asian, Middle Eastern, Black and Caucasian) were recruited at 27\u00a0weeks gestation and randomized into three treatment groups: a single oral dose of 200\u00a0000\u00a0IU vitamin D, a daily supplement of 800\u00a0IU vitamin D from 27\u00a0weeks until delivery and a no treatment group.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Vitamin D (25\u2010hydroxyvitamin D), PTH and corrected calcium levels in mothers at 27\u00a0weeks and at delivery and cord 25\u2010hydroxyvitamin D and corrected calcium levels.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The final maternal 25\u2010hydroxyvitamin D levels were significantly higher in the supplemented group [daily dose (median) 42 (IQR 31\u201376) nmol\/l, stat dose (median) 34 (IQR 30\u201346) nmol\/l <jats:italic>vs.<\/jats:italic> median 27 (IQR 27\u201339) nmol\/l in the no treatment; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001] and significantly fewer women with secondary hyperparathyroidism in the supplemented group (10% in daily dose <jats:italic>vs.<\/jats:italic> 12% in stat dose <jats:italic>vs.<\/jats:italic> 27% in the no treatment; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Cord 25\u2010hydroxyvitamin D levels were significantly higher with supplementation [daily dose median 26 (IQR 17\u201345) nmol\/l, stat dose median 25 (IQR 18\u201334) nmol\/l <jats:italic>vs.<\/jats:italic> median 17 (IQR 14\u201322) nmol\/l in no treatment; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001].<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Single or daily dose improved 25\u2010hydroxyvitamin D levels significantly. However, even with supplementation, only a small percentage of women and babies were vitamin D sufficient. Further research is required to determine the optimal timing and dosing of vitamin D in pregnancy.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03403.x","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T09:45:29Z","timestamp":1220348729000},"page":"685-690","source":"Crossref","is-referenced-by-count":159,"title":["Vitamin D deficiency and supplementation during pregnancy"],"prefix":"10.1111","volume":"70","author":[{"given":"C. K. H.","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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