{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:52:30Z","timestamp":1773276750301,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,9,5]],"date-time":"2008-09-05T00:00:00Z","timestamp":1220572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Hypothyroidism is associated with elevated cardiovascular risk, not fully explained by classical risk factors. Instead, endothelial dysfunction may link hypothyroidism to atherosclerosis. The effect of levothyroxine substitution on endothelial function has been sparsely studied and the results are unclear. This study tested endothelial function as estimated by concomitant measurements of endothelial dependent vascular dilatory capacity and plasma concentration of von Willebrand factor antigen in patients with hypothyroidism and further examined the impact of subsequent levothyroxine substitution.<\/jats:p><jats:p><jats:bold>Design and patients\u2002<\/jats:bold> Sixteen consecutive patients (13 women, 3 men, aged 46\u00a0\u00b1\u00a011\u00a0years) with hypothyroidism were included and compared to 16 matched healthy controls (13 women, 3 men, aged 49\u00a0\u00b1\u00a011\u00a0years). Patients with hypothyroidism were reexamined after 3, 6 and 12\u00a0months of levothyroxine substitution.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> Dilatory responses of the brachial artery to post\u2010ischaemic increased blood flow (endothelium\u2010dependent flow\u2010associated dilatation) and to nitroglycerin (endothelium\u2010independent nitroglycerin induced dilatation) were measured by ultrasound. Plasma concentrations of von Willebrand factor antigen were measured by ELISA.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Flow\u2010associated dilatation was impaired in patients with hypothyroidism as compared to controls (102\u00b77\u00a0\u00b1\u00a03\u00b76 <jats:italic>vs.<\/jats:italic> 105\u00b76\u00a0\u00b1\u00a03\u00b78%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704) whereas no differences in plasma concentration of von Willebrand factor antigen were found. One year levothyroxine substitution did not improve flow\u2010associated dilatation and was associated with an increase of the plasma von Willebrand factor antigen concentration.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Hypothyroid patients are characterized by endothelial dysfunction sustained despite long\u2010term levothyroxine substitution and potentially increasing the risk of atherosclerosis. Different estimates of endothelial dysfunction seem unequally influenced by hypothyroidism.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03410.x","type":"journal-article","created":{"date-parts":[[2008,9,5]],"date-time":"2008-09-05T09:28:20Z","timestamp":1220606900000},"page":"932-937","source":"Crossref","is-referenced-by-count":19,"title":["Hypothyroidism is associated with signs of endothelial dysfunction despite 1\u2010year replacement therapy with 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