{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:30:40Z","timestamp":1761539440231,"version":"3.35.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,9]],"date-time":"2008-11-09T00:00:00Z","timestamp":1226188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>Autoimmune thyroiditis and overt or subclinical hypothyroidism have been associated with increased prevalence of cardiovascular disease (CVD).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold>Cross\u2010sectional investigation of the association between gene polymorphisms related to CVD with thyroid function and autoimmunity.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold>In total 84 healthy postmenopausal women aged 49\u201369\u00a0years.<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold>FT3, FT4, anti\u2010TPO and anti\u2010TG were assessed in the sera of participants. The following polymorphisms were assessed from peripheral lymphocyte DNA: Apolipoprotein E E2\/E3\/E4, paraoxonase 1\u00a0A\/B, Glycoprotein IIIa leu33pro, MTHFR ala222val, ApoBarg3500gln, plasminogen activator inhibitor 1 4G\/5G, cholesterol 7\u2010\u03b1 hydroxylase A204C and cholesterol ester transfer protein B1\/B2.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>A statistically significant correlation was found between Apolipoprotein E and paraoxonase1 polymorphisms and serum thyroid hormones: carriers of the E2 or E4 allele of the ApoE gene had lower levels of FT4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70005) than women with the E3\/E3 genotype. Carriers of the B allele of paraoxonase 1 gene had lower levels of FT3 compared to women with the wild\u2010type genotype (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7047). A statistically significant positive association (<jats:italic>P\u00a0=<\/jats:italic>\u00a00\u00b7049) was also observed between anti\u2010TG antibodies and the presence of the E2 allele of the Apolipoprotein E gene.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>Polymorphisms of apolipoprotein E and paraoxonase 1 are associated with different levels of thyroid hormone and anti\u2010Tg antibody levels in the study population in this pilot study. The mechanism underlying this association remains to be elucidated.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2008.03476.x","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T02:28:20Z","timestamp":1226284100000},"page":"284-290","source":"Crossref","is-referenced-by-count":6,"title":["Apolipoprotein E and Paraoxonase 1 polymorphisms are associated with lower serum thyroid hormones in postmenopausal women"],"prefix":"10.1111","volume":"71","author":[{"given":"Irene","family":"Lambrinoudaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Kaparos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrios","family":"Rizos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotini","family":"Galapi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Alexandrou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros N.","family":"Sergentanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Creatsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Christodoulakos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kouskouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Botsis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072502761016458"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2006.2.4.499"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2005.15.718"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:24:1:001"},{"key":"e_1_2_5_6_2","first-page":"149","article-title":"Apolipoprotein E genotypes and metabolic risk factors for coronary heart disease in middle\u2010aged women","volume":"22","author":"Cubrilo\u2010Turek M.","year":"1998","journal-title":"Collegium Antropologicum"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/345312"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382203"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/S0022-2275(20)34905-1","article-title":"Association of the A\u2010204C polymorphism in the cholesterol 7\u2010hydroxylase gene with variations in plasma low density lipoprotein cholesterol levels in the Framingham Offspring Study","volume":"40","author":"Couture P.","year":"1999","journal-title":"Journal of Lipid Research"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.5.1323"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2006.00584.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341703"},{"key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.33588\/rn.4310.2005542","article-title":"Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in ischemic vascular disease","volume":"43","author":"S\u00e1nchez\u2010Mar\u00edn B.","year":"2006","journal-title":"Review Neurology"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bss0670101"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/MI\/2006\/12587"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2003.10.015"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00459-8"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.11.6.394"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.2143\/AC.59.6.2005242"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.12.100"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20099"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-006-1390-4"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:112:1:57"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.12.018"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0654-6"},{"key":"e_1_2_5_26_2","first-page":"293","article-title":"The role of oxidative stress in physiological and pathological processes in the thyroid gland; 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