{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:53:06Z","timestamp":1780649586208,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T00:00:00Z","timestamp":1234915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>We evaluated the German Acromegaly Register for clinical variables associated with the initial biochemical activity of patients with acromegaly.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold>Retrospective analysis of data in the registry.<\/jats:p><jats:p><jats:bold>Patients\u2003<\/jats:bold>A total of 1485 patients with acromegaly (males 45\u00b76%, females 54\u00b74%) were treated in 42 German endocrine centres until November 2005. Linear regression models were used to estimate the influence of various parameters on biochemical activity.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Male patients with acromegaly were significantly younger at the time of diagnosis than female patients (41<jats:italic>vs.<\/jats:italic>47\u2003years,<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b70001) and had significantly higher random GH levels than females (21<jats:italic>vs.<\/jats:italic>14\u2003ng\/ml,<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b7005) and IGF\u20101 levels (773<jats:italic>vs.<\/jats:italic>679\u2003ng\/ml,<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b70001), respectively. Age at initial presentation turned out to be the most important independent risk factor associated with random GH levels, oral glucose tolerance test\u2010suppressed GH levels, IGF\u20101 levels, body mass index (BMI), tumour size and prevalence of hypopituitarism. Sex was an independent risk factor for IGF\u20101 levels, BMI and prevalence of hypopituitarism. Tumour size was an independent risk factor for both GH and IGF\u20101 levels.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold>In summary, initial biochemical activity of acromegaly is influenced by patient\u2019s age and to a lesser degree by patient\u2019s sex. Male patients are on an average 6\u2003years younger than females.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2009.03547.x","type":"journal-article","created":{"date-parts":[[2009,2,18]],"date-time":"2009-02-18T13:58:21Z","timestamp":1234965501000},"page":"400-405","source":"Crossref","is-referenced-by-count":39,"title":["Age and sex as predictors of biochemical activity in acromegaly: analysis of 1485 patients from the German Acromegaly Register"],"prefix":"10.1111","volume":"71","author":[{"given":"S.","family":"Petersenn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Buchfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Gerbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Quabbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. M.","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Grussendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Reincke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Participants of the German Acromegaly Register","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-59259-217-3_4","volume-title":"Diagnosis and Management of Pituitary Tumors","author":"Yamada S.","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1668"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03221.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-948313"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1616"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-006-7557-4"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071871"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002340050839"},{"issue":"1","key":"e_1_2_6_10_2","first-page":"555","article-title":"Indications, limitations and pitfalls in the determination of human growth hormone, IGF\u2010I and their binding proteins","volume":"5","author":"Laron Z.","year":"2007","journal-title":"Pediatric Endocrinology Reviews"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000080504"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1210\/jcem.86.11.8006","article-title":"The relationship between serum GH and serum IGF\u2010I in acromegaly is gender\u2010specific","volume":"86","author":"Parkinson C.","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345496"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1381"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.3.1121"},{"issue":"1","key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000080762","article-title":"Serum insulin\u2010like growth factor I levels in growth hormone\u2010deficient adults: influence of sex steroids","volume":"62","author":"Jorgensen J.O.","year":"2004","journal-title":"Hormone Research"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02676.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02304.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1400383"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","unstructured":"Petersenn S. 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Reincke M.et\u00a0al.(2007)Primary surgical therapy of acromegaly \u2013 results and prognostic parameters from the German acromegaly register. 51st Annual Meeting of the German Society of Endocrinology (DGE) Vol. 115 (S1) Salzburg Abstract.","DOI":"10.1055\/s-2007-972491"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02763.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020453"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2009.03547.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2009.03547.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T20:05:34Z","timestamp":1738958734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2009.03547.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,14]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1111\/j.1365-2265.2009.03547.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03547.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,14]]}}}