{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:06:44Z","timestamp":1770962804173,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T00:00:00Z","timestamp":1307664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Context\u2002<\/jats:bold> Premature pubarche (PP) is reported in children with Prader\u2013Willi Syndrome (PWS). Pubarche is preceded by adrenarche \u2013 an increase in serum levels of adrenal androgens, most specifically dehydroepiandrosterone sulphate (DHEAS).<\/jats:p><jats:p><jats:bold>Objectives\u2002<\/jats:bold> To assess DHEAS levels, the age at and progression of pubarche and the prevalence of PP in children with PWS.<\/jats:p><jats:p><jats:bold>Design\/Patients\u2002<\/jats:bold> In the Dutch PWS Cohort Study, 120 children (6\u2003months\u201317\u2003years) are prospectively followed. Their age at onset of pubarche and various pubic hair stages and prevalence of PP were determined. Serum DHEAS levels were assessed in 97 children.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Median serum DHEAS levels were significantly higher in children with PWS than in healthy age\u2010matched controls at ages 3\u20136\u2003years (girls: <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7004 and boys: <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7010) and 6\u201310\u2003years (girls: <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7045 and boys: <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7001). Age and gender significantly influenced DHEAS levels in children with PWS. The median [P10\u2013P90] age at onset of pubarche in children with PWS was significantly younger than in healthy peers, 9\u00b704[6\u00b775\u201311\u00b784] years in PWS girls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030\u00b70001) and 10\u00b731 [8\u00b765\u201312\u00b729] years in PWS boys (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7003). The prevalence of PP in children with PWS was 30\u00b70% in girls and 16\u00b71% in boys.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Compared to healthy children, children with PWS have significantly higher DHEAS levels from 3 to 10\u2003years of age. They are younger at onset of pubarche and have a higher prevalence of premature pubarche. DHEAS levels in PWS are influenced by age and gender. Our findings indicate earlier maturation of the zona reticularis of the adrenal glands in children with PWS.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.03989.x","type":"journal-article","created":{"date-parts":[[2011,1,20]],"date-time":"2011-01-20T15:54:18Z","timestamp":1295538858000},"page":"83-89","source":"Crossref","is-referenced-by-count":33,"title":["Pubarche and serum dehydroepiandrosterone sulphate levels in children with Prader\u2013Willi syndrome"],"prefix":"10.1111","volume":"75","author":[{"given":"Elbrich P. C.","family":"Siemensma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick F. A.","family":"de Lind van Wijngaarden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barto J.","family":"Otten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank H.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita C. 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