{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:19:49Z","timestamp":1791850789846,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T00:00:00Z","timestamp":1323216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> ShearWave\u2122 Elastography (SWE) is real\u2010time, quantitative and user\u2010independent technique, recently introduced in the diagnostic work\u2010up of thyroid nodules. Hashimoto\u2019s thyroiditis (HT), characterized by variable degrees of lymphocytic infiltration and fibrosis, might affect shear wave propagation. The aim of this study was to assess the feasibility of SWE in cytologically benign thyroid nodules within both Hashimoto\u2019s and nonautoimmune thyroid glands. The effect of autoimmunity on the gland stiffness was also evaluated.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> longitudinal study in a single centre.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> SWE was performed in 75 patients with a benign thyroid nodule at cytology: 33 with Hashimoto\u2019s thyroiditis (HT group) and 42 with uni\u2010 or multi\u2010nodular goitre, negative for thyroid autoimmunity (non\u2010HT group).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The elasticity index (EI) of the extra\u2010nodular tissue was greater, though not statistically significant, in the HT than in the non\u2010HT group (24\u00b70\u2003\u00b1\u200310\u00b75\u2003kPa <jats:italic>vs<\/jats:italic> 20\u00b78\u2003\u00b1\u200310\u00b74\u2003kPa; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7206). However, the EI of extra\u2010nodular tissue was related to the TPOAb titre in the HT group (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b702) and was significantly higher in patients with HT receiving L\u2010thyroxine than in the euthyroid subjects (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b702). The EI of thyroid nodules was similar in HT and non\u2010HT groups. In both groups, the stiffness of nodules was significantly higher than that of the embedding tissue.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Our data indicate that SWE correctly defines the elasticity of thyroid nodules independently from the coexistence of autoimmune thyroiditis, always being able to differentiate nodular tissue from the surrounding parenchyma. In HT, the stiffness of extra\u2010nodular tissue increases in relation to both the thyroid antibody titre and the degree of impairment of thyroid function.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.04170.x","type":"journal-article","created":{"date-parts":[[2011,7,9]],"date-time":"2011-07-09T15:20:26Z","timestamp":1310224826000},"page":"137-141","source":"Crossref","is-referenced-by-count":105,"title":["Shear wave elastography in the diagnosis of thyroid nodules: feasibility in the case of coexistent chronic autoimmune Hashimoto\u2019s 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