{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:28:21Z","timestamp":1793917701177,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T00:00:00Z","timestamp":1335139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> To develop a disease\u2010specific questionnaire for Cushing\u2019s disease (CD), the Tuebingen Cushing\u2019s disease quality of life inventory (Tuebingen CD\u201025).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Sources for item generation consisted of technical literature, interviews with patients and the rating of neurosurgeons, endocrinologists and a neuropsychologist. A preliminary inventory with 64 items was handed out to 63 CD patients. Twenty\u2010eight patients filled out the questionnaire preoperative, the remaining 35 patients evaluated their health\u2010related quality of life (HRQoL) retrospectively. Item reduction and scale generation followed the principles of classical test theory. Validation was performed with the WHOQoL\u2010BREF.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The final version of the Tuebingen CD\u201025 contained 25 items, showed high reliability (Cronbach\u2019s alpha\u2003=\u20030\u00b793) and validity (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120\u00b765) and includes the subdomains Depression, Sexual Activity, Environment, Eating Behaviour, Bodily Restrictions and Cognition. The retrospective rating of the Tuebingen CD\u201025 showed similar results compared to the pretreatment group. We found a non\u2010linear correlation between the Tuebingen CD\u201025 scores and patients\u2019 age, younger (21\u201330\u2003years) and middle\u2010aged (51\u201360\u2003years) patients having inferior HRQoL than patients between 31 and 50\u2003years and older than 61\u2003years. Preoperative 24\u2003h urinary free cortisol (UFC) levels correlated significantly with the subscale Cognition and only marginally failed significance level for the subscale Eating Behaviour, while preoperative cortisol and ACTH levels did not correlate with any scale.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> The Tuebingen CD\u201025 is a valid and reliable instrument to evaluate HRQoL in CD. Based on impairment of HRQoL for the different subdimensions, specific support can be offered to the patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.04191.x","type":"journal-article","created":{"date-parts":[[2011,7,29]],"date-time":"2011-07-29T20:50:26Z","timestamp":1311972626000},"page":"851-860","source":"Crossref","is-referenced-by-count":33,"title":["The development of the Tuebingen Cushing\u2019s disease quality of life inventory (Tuebingen CD\u201025). 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