{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:11:45Z","timestamp":1770437505998,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Context\u2002<\/jats:bold> We aimed to assess whether obstructive sleep apnoea syndrome (OSAS) affects plasma IGF\u20101 and dehydroepiandrosterone sulphate (DHEA\u2010S) levels in men, factors implicated in the development of age\u2010related metabolic disorders.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> We conducted a cross\u2010sectional and longitudinal clinical study.<\/jats:p><jats:p><jats:bold>Patients and setting\u2002<\/jats:bold> We measured plasma IGF\u20101 and DHEA\u2010S levels in 191 non\u2013drug\u2010treated Japanese men (34 primary snorers (PS), 88 patients with mild\u2010to\u2010moderate OSAS and 69 patients severe OSAS ).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Plasma IGF\u20101 and DHEA\u2010S were negatively correlated with age. Plasma IGF\u20101 was also negatively correlated with plasma glucose, HOMA\u2010IR and systolic blood pressure and apnoea parameters such as the apnoea\u2013hypopnea index, minimum oxygen saturation and slow\u2010wave sleep (SWS) time. Plasma DHEA\u2010S was associated with plasma glucose, HbA1c and free fatty acid and was negatively correlated with SWS time. To eliminate the influence of age, PS, patients with mild\u2010to\u2010moderate OSAS and severe OSAS were divided into three groups by age: young (&lt;40\u2003years), middle\u2010aged (40\u201359\u2003years) and elderly (\u226560\u2003years). Patients with severe OSAS aged &lt;40 or &lt;60\u2003years had lower plasma IGF\u20101 or DHEA\u2010S levels, respectively, than did the corresponding snorers and mild\u2010to\u2010moderate OSAS groups. Continuous positive airway pressure therapy for generally 16\u201318\u2003months increased plasma IGF\u20101 levels in patients with severe OSAS aged &lt;40\u2003years (<jats:italic>n<\/jats:italic>\u2003=\u200318). Plasma DHEA\u2010S levels were increased in patients with severe OSAS aged &lt;60\u2003years, whose DHEA\u2010S level was below the mean value for that age (<jats:italic>n<\/jats:italic>\u2003=\u200323\/41).<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Severe OSAS could reduce plasma IGF\u20101 and DHEA\u2010S levels in younger, but not elderly Japanese men, which is potentially associated with the development of metabolic abnormalities.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.04237.x","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T01:40:33Z","timestamp":1317174033000},"page":"593-601","source":"Crossref","is-referenced-by-count":18,"title":["Plasma dehydroepiandrosterone sulphate and insulin\u2010like growth factor I levels in obstructive sleep apnoea 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