{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:56:59Z","timestamp":1785455819894,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T00:00:00Z","timestamp":1328572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> The natural history of Hashimoto\u2019s thyroiditis (HT) and isolated hyperthyrotropinaemia (IH) is not well defined. We therefore studied the natural course of patients with HT and IH and looked for possible prognostic factors.<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> This is retrospective cross\u2010sectional study.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Three hundred and twenty\u2010three patients with HT (88 boys and 235 girls) and 59 with IH (30 boys and 29 girls), mean age 9\u00b79\u2003\u00b1\u20033\u00b78\u2003years were included in the study. When first examined, 236 of the children with HT had a normal TSH (G0) and in 87, it was elevated but &lt;100% of the upper limit (G1). All IH subjects had elevated TSH. Potential risk factors for thyroid failure were evaluated after 3\u2003years and included the presence or familiarity for endocrine\/autoimmune diseases, premature birth, signs and symptoms of hypothyroidism, TSH levels, antithyroid antibodies and thyroid volume.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> HT: Of those with HT, 170\u2003G0 patients remained stable, 31 moved to G1 and 35 to G2 (hypothyroidism). Thirty\u2010six G1 children moved to G0, 17 remained stable and 34 moved to G2. Of patients with IH: 23 normalized, 28 remained stable and eight became overtly hypothyroid. In patients with HT, the presence of coeliac disease, elevated TSH and thyroid peroxidase antibodies (TPOAb) increased the risk of developing hypothyroidism by 4\u00b70\u2010, 3\u00b74\u2010 and 3\u00b75\u2010fold, respectively. The increase in TSH levels during follow\u2010up was strongly predictive of the development of hypothyroidism. In patients with IH, no predictive factor could be identified.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Coeliac disease, elevated TSH and TPOAb at presentation and a progressive increase in TSH are predictive factors for thyroid failure in HT patients.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.04251.x","type":"journal-article","created":{"date-parts":[[2011,10,10]],"date-time":"2011-10-10T18:27:14Z","timestamp":1318271234000},"page":"394-398","source":"Crossref","is-referenced-by-count":75,"title":["The natural history of the normal\/mild elevated TSH serum levels in children and adolescents with Hashimoto\u2019s thyroiditis and isolated hyperthyrotropinaemia: a 3\u2010year 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