{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:13:13Z","timestamp":1790982793482,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T00:00:00Z","timestamp":1333584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"Summary<\/jats:title>\n \n Objective\u2002<\/jats:bold>\n Patients on long\u2010term dialysis may develop secondary hyperparathyroidism (SHPT), which causes varying degrees of bone mass loss. This condition is treated with parathyroidectomy (PTX). We investigated whether serial serum bone turnover markers could predict changes in bone mineral density (BMD) after PTX.\n <\/jats:p>\n \n Design and patients\u2002<\/jats:bold>\n Renal patients on maintenance haemodialysis who received PTX for refractory SHPT (\n n<\/jats:italic>\n \u2003=\u200326, male\/female: 13\/13; mean age: 48\u00b76\u2003\u00b1\u200310\u00b77\u2003year) and control subjects without SHPT (\n n<\/jats:italic>\n \u2003=\u200325) were prospectively followed for 1\u2003year at two tertiary hospitals in Taiwan.\n <\/jats:p>\n \n Measurements\u2002<\/jats:bold>\n Serum intact parathyroid hormone (iPTH), bone\u2010specific alkaline phosphatase (BAP) and type 5b tartrate\u2010resistant acid phosphatase (TRAP) were measured serially. Additionally, femoral neck (FN) and lumbar spine (LS) BMD were measured before and 1\u2003year after PTX.\n <\/jats:p>\n \n Results\u2002<\/jats:bold>\n After PTX, iPTH levels decreased markedly and persistently. BMDs increased in both the FN and LS, but particularly in the LS. Serum BAP progressively increased to a peak at 2\u2003weeks after PTX. Serum TRAP levels progressively decreased over 6\u2003months after PTX. In univariate correlation analyses, baseline iPTH correlated positively with\n T<\/jats:italic>\n \u2010score changes in FN (\n r<\/jats:italic>\n \u2003=\u20030\u00b745,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b7021) and LS (\n r<\/jats:italic>\n \u2003=\u20030\u00b748,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b7013). In multivariate regression models, changes in FN\n T<\/jats:italic>\n \u2010scores were negatively predicted by baseline BAP levels (\n r\u2003<\/jats:italic>\n =\u2003\u22120\u00b7615,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b7005) and baseline FN\n T<\/jats:italic>\n \u2010scores (\n r<\/jats:italic>\n \u2003=\u2003\u22120\u00b7563,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b7012), and they were positively predicted by baseline TRAP(\n r<\/jats:italic>\n \u2003=\u20030\u00b76,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b7007). Changes in LS\n T<\/jats:italic>\n \u2010scores were positively predicted by baseline TRAP values (\n r<\/jats:italic>\n \u2003=\u20030\u00b7528,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b701) and negatively predicted by the percentage change in BAP after 2\u2003weeks (\n r\u2003<\/jats:italic>\n =\u2003\u22120\u00b7501,\n P\u2003<\/jats:italic>\n =\n \u2003<\/jats:italic>\n 0\u00b7015).\n <\/jats:p>\n \n Conclusions\u2002<\/jats:bold>\n Parathyroidectomy provided marked, sustained improvements in BMD for up to 1\u2003year. Furthermore, markers of bone turnover predicted 1\u2010year changes in FN and LS BMDs after PTX.\n <\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.04265.x","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T09:30:31Z","timestamp":1318930231000},"page":"634-642","source":"Crossref","is-referenced-by-count":47,"title":["Bone turnover markers predict changes in bone mineral density after parathyroidectomy in patients with renal 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