{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T10:16:38Z","timestamp":1780827398521,"version":"3.54.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold> Vitamin D deficiency has been associated in some studies with nonspecific musculoskeletal pain and, more specifically, with statin\u2010induced myalgia, which was ameliorated by high\u2010dose vitamin D supplements. Our objective was to explore the association between vitamin D status and statin\u2010induced myalgia and elevation of serum creatine kinase (CK).<\/jats:p><jats:p><jats:bold>Design\u2002<\/jats:bold> Retrospective cohort study, based on the electronic database of a health maintenance organization.<\/jats:p><jats:p><jats:bold>Patients\u2002<\/jats:bold> Six thousand eight hundred and eight patients (71\u00b75% women) to whom statins were dispensed during 2008 and who had \u22651 CK and 25\u2010hydroxy vitamin D (25OHD) levels measured during statin exposure. Of these, 376 patients (5\u00b75%) had switched from a first\u2010line statin to atorvastatin because of muscle pain (<jats:italic>n<\/jats:italic>\u2003=\u2003220) or other reasons (<jats:italic>n<\/jats:italic>\u2003=\u2003156).<\/jats:p><jats:p><jats:bold>Measurements\u2002<\/jats:bold> In the entire cohort, we compared serum CK levels among serum 25OHD quartiles. In addition, we compared CK and 25OHD levels among patients with myalgia, other switchers and nonswitchers.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The median 25OHD level in the entire cohort was 21\u00b78\u2003ng\/ml [interquartile range (IQR), 16\u00b73\u201327\u00b74]. CK levels were marginally lower in patients in the lowest 25OHD quartile [median CK (IQR) in 25OHD quartiles 1\u20134, 87 (61\u2013130), 90 (65\u2013131), 91 (65\u2013132) and 91 (67\u2013131)\u2003IU\/ml, respectively; <jats:italic>P<\/jats:italic>\u2003=\u20030\u00b7007]. 25OHD levels in statin switchers were similar to those in nonswitchers; moreover, there were no differences in 25OHD among switchers with muscle pain and other switchers.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> Our findings do not support an association between low 25OHD levels and statin\u2010induced myalgia or CK elevation.<\/jats:p>","DOI":"10.1111\/j.1365-2265.2011.04321.x","type":"journal-article","created":{"date-parts":[[2011,12,25]],"date-time":"2011-12-25T00:13:21Z","timestamp":1324772001000},"page":"36-41","source":"Crossref","is-referenced-by-count":46,"title":["Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving 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