{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:39:09Z","timestamp":1791916749030,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sympathovagal imbalance has been shown in acromegaly by indirect measurements of adrenergic tone. Data regarding direct measurement of sympathetic activity are lacking as yet. Aim of this study was to assess the adrenergic tone through direct recording of muscle sympathetic nerve activity (<jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content>) in acromegalic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Fifteen patients (age 26\u201366\u00a0years, eight women) with newly diagnosed active acromegaly without hyperprolactinaemia, pituitary hormone deficiencies, obstructive sleep apnoea and cardiac hypertrophy, and 15 healthy subjects matched for age, sex and body mass index were recruited. After evaluating anthropometric and echocardiographic parameters, anterior pituitary function, glucose and lipid metabolism, and measuring plasma leptin, direct recording of sympathetic outflow via the microneurographic technique was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For similar anthropometric and metabolic parameters in patients and controls, <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content> index was significantly increased in the former (4\u00b72\u00a0\u00b1\u00a02\u00b739 <jats:italic>vs<\/jats:italic> 1\u00b76\u00a0\u00b1\u00a00\u00b719, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). Surprisingly, this finding of insulin resistance was accompanied by a marked sympathetic inhibition (<jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> 18\u00b73\u00a0\u00b1\u00a08\u00b710 <jats:italic>vs<\/jats:italic> 37\u00b73\u00a0\u00b1 6\u00b748\u00a0bursts\/min, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001, respectively in patients and controls). A reduction in plasma leptin (1\u00b76\u00a0\u00b1\u00a01\u00b704 <jats:italic>vs<\/jats:italic> 6\u00b75\u00a0\u00b1\u00a02\u00b701\u00a0\u03bcg\/l, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001) was also recorded in the patients. <jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> was positively correlated with leptin (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Newly diagnosed acromegalic patients without cardiac hypertrophy display a decreased sympathetic outflow in spite of insulin resistance. This finding might be related to hypoleptinaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04335.x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T17:52:29Z","timestamp":1326217949000},"page":"262-267","source":"Crossref","is-referenced-by-count":8,"title":["Decreased adrenergic tone in acromegaly: evidence from direct recording of muscle sympathetic nerve activity"],"prefix":"10.1111","volume":"77","author":[{"given":"G.","family":"Seravalle","sequence":"first","affiliation":[{"name":"Department of Cardiology Ospedale San Luca IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Carzaniga","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medical Sciences University of Milan Ospedale San Luca IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Attanasio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Istituto Galeazzi Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Grassi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Prevention University of Milano\u2010Bicocca Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lonati","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale San Luca IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Facchini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ospedale San Luca IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Ospedale Niguarda Ca' Granda Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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