{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:33:42Z","timestamp":1791178422869,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:00:00Z","timestamp":1355184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Glucocorticoid therapy may result in adipose tissue redistribution of unknown pathophysiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effects of glucocorticoids on adipokine levels and adipose tissue inflammation. To compare the results in patients with or without glucocorticoid\u2010induced lipodystrophy (GIL) after 3\u00a0months of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Prospective monocentric study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Adult patients <jats:italic>initiating<\/jats:italic> systemic, high\u2010dose prednisone therapy for at least 3\u00a0months. Blood samples and subcutaneous abdominal adipose tissue biopsies were collected at baseline and month 3. The presence of GIL after 3\u00a0months of therapy was assessed using standardized photography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two patients were enrolled. Blood samples and subcutaneous abdominal adipose tissue were available at baseline and month 3 for 30 patients [median age: 61 (38\u201379) years, 77% women]. Among those 30 patients, 15 were classified as GIL+ and 15 were GIL\u2212 at month 3. Between baseline and month 3, adiponectin and leptin levels increased in the overall population while the level of resistin remained unchanged. At baseline, leptin level was higher [19\u00b73 (8\u00b73\u201331\u00b71) <jats:italic>vs<\/jats:italic> 4\u00b75 (2\u00b74\u201311\u00b73) \u03bcg\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006] and resistin level lower [7\u00b71 (6\u00b73\u201312\u00b74) <jats:italic>vs<\/jats:italic> 10\u00b74 (8\u00b70\u201321\u00b77) \u03bcg\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705] in GIL+ than in GIL\u2212 patients. Baseline leptin level was predictive of GIL occurrence. Receiver operating characteristic curve analysis demonstrated that the best diagnostic accuracy was obtained with a baseline leptin cut\u2010off of 5\u00b79\u00a0\u03bcg\/l (sensitivity: 93%, specificity: 60%). At month 3, leptin and adiponectin levels increased more in the GIL+ than in the GIL\u2212 group, as did the number of anti\u2010inflammatory M2 macrophages in subcutaneous abdominal fat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Glucocorticoid\u2010induced lipodystrophy is associated with a different adipokine profile both before and after glucocorticoid therapy. Serum leptin level prior to glucocorticoid therapy is highly predictive of GIL occurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04348.x","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T11:36:43Z","timestamp":1327405003000},"page":"43-51","source":"Crossref","is-referenced-by-count":20,"title":["Adipokine profile in glucocorticoid\u2010treated patients: baseline plasma leptin level predicts occurrence of lipodystrophy"],"prefix":"10.1111","volume":"78","author":[{"given":"Laurence","family":"Fardet","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Interne AP\u2010HP H\u00f4pital Saint\u2010Antoine"},{"name":"Facult\u00e9 de m\u00e9decine Universit\u00e9 Pierre et Marie Curie UPMC Paris 6"},{"name":"INSERM UMR\u2010S938"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Antuna\u2010Puente","sequence":"additional","affiliation":[{"name":"INSERM 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