{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:27:08Z","timestamp":1760549228663},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Addition of dehydroepiandrosterone sulphate (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content>) to standard pituitary replacement may improve quality of life and glucose metabolism. Conflicting results from the previous work probably relate to differences in populations studied and assessment techniques used. We examined the effects of <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> on insulin action and the quality of life in female patients with hypopituitary hypoadrenalism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Randomized, double\u2010blind, placebo\u2010controlled, crossover design was used. Patients received either <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> 50\u00a0mg daily or placebo for 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Fourteen hypopituitary females on stable standard replacement therapy and with low <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> were enrolled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Insulin action by euglycaemic hyperinsulinaemic clamp and extensive quality of life parameters were assessed after each treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> 5\u00b74\u00a0\u00b1\u00a00\u00b78 <jats:italic>vs<\/jats:italic> placebo &lt;0\u00b78\u00a0\u00b1 0\u00b70\u00a0\u03bc<jats:sc>m<\/jats:sc>;<jats:italic> P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and androstenedione (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> 4\u00b71\u00a0\u00b1\u00a00\u00b78 <jats:italic>vs<\/jats:italic> placebo 1\u00b73\u00a0\u00b1\u00a00\u00b72\u00a0n<jats:sc>m<\/jats:sc>;<jats:italic> P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) rose to within the normal range after <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> 50\u00a0mg daily. There were no differences between treatments in testosterone, sex hormone\u2010binding globulin (<jats:styled-content style=\"fixed-case\">SHBG<\/jats:styled-content>) or <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20101. Quality of life measures were unchanged after <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content>. There were no differences between treatments in fasting glucose, serum insulin, HbA1c or in insulin action (glucose infusion rates required to maintain euglycaemia; <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> 21\u00b79\u00a0\u00b1\u00a02\u00b75 <jats:italic>vs<\/jats:italic> placebo 24\u00b75\u00a0\u00b1\u00a02\u00b71\u00a0\u03bcmol\/kg\/min; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b74). Triglyceride concentrations were lower following <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> 1\u00b724\u00a0\u00b1\u00a00\u00b718 <jats:italic>vs<\/jats:italic> placebo 1\u00b741\u00a0\u00b1\u00a00\u00b719\u00a0m<jats:sc>m<\/jats:sc>;<jats:italic> P<\/jats:italic>\u00a0&lt;\u00a00\u00b705) but other lipid parameters remained unchanged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were no differences compared with placebo in quality of life or insulin action after <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> replacement therapy for 12\u00a0weeks. These results do not provide evidence for the addition of <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> to standard hypopituitary replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04356.x","type":"journal-article","created":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T17:48:41Z","timestamp":1331833721000},"page":"423-429","source":"Crossref","is-referenced-by-count":10,"title":["Effects of dehydroepiandrosterone sulphate (<scp>DHEAS<\/scp>) replacement on insulin action and quality of life in hypopituitary females: a double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1111","volume":"77","author":[{"given":"Claire M.","family":"McHenry","sequence":"first","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick M.","family":"Bell","sequence":"additional","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Beaumont Hospital\/RCSI Medical School Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Courtney","sequence":"additional","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cieran N.","family":"Ennis","sequence":"additional","affiliation":[{"name":"Regional Endocrine Laboratory Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Regional Endocrine Laboratory Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"McCance","sequence":"additional","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen R.","family":"Mullan","sequence":"additional","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Brew","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Regional Centre for Endocrinology and Diabetes Royal Victoria Hospital Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.561"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2002.01466.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01799.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909303411401"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4650"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0316"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.5.1968"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2046"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.765"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1802"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054629"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02750.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1134"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2636"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1774"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91812-O"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01017.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6949.226"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400570"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/ajplegacy.1956.187.1.15","article-title":"Measurement of size and turnover rate of body glucose pool by the isotope dilution method","volume":"187","author":"Steele R.","year":"1956","journal-title":"American Journal of Physiology"},{"key":"e_1_2_8_24_1","first-page":"445","article-title":"On the hormonal regulation of carbohydrate metabolism; studies with C14 glucose","volume":"19","author":"De Bodo R.C.","year":"1996","journal-title":"Recent Progress in Hormone Research"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050363"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.3.1169"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.1.153"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90245-3"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.237.3.E214"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02648.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2012.04356.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2012.04356.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:38:38Z","timestamp":1695490718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2012.04356.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,14]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1111\/j.1365-2265.2012.04356.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2012.04356.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,14]]}}}