{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:36:49Z","timestamp":1785569809969,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T00:00:00Z","timestamp":1338940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) is a heterogeneous disorder where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. It has recently been shown that the <jats:styled-content style=\"fixed-case\"><jats:italic>FTO<\/jats:italic><\/jats:styled-content> gene modifies weight, fat mass and insulin sensitivity in women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, where its role might be larger than in other phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to estimate the effect of a variation of the <jats:styled-content style=\"fixed-case\"><jats:italic>FTO<\/jats:italic><\/jats:styled-content> gene on carbohydrate and lipid oxidation in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>The study group consisted of 65 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and 28 healthy, normally menstruating women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Clinical examination, anthropometric measurements, euglycaemic hyperinsulinaemic clamp and measurements of serum sex hormones were performed. Carbohydrate and lipid oxidation were evaluated with indirect calorimetry in the baseline state and during last 30\u00a0min of the clamp. The <jats:styled-content style=\"fixed-case\"><jats:italic>FTO<\/jats:italic><\/jats:styled-content> rs9939609 polymorphism was genotyped using the restriction fragment length polymorphism method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in carbohydrate and lipid oxidation between <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and control women. In the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> group, <jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content> homozygotes had higher baseline fat oxidation in comparison with carriers of the A allele (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018), which was not found in the control group. We did not observe the effect of the <jats:styled-content style=\"fixed-case\"><jats:italic>FTO<\/jats:italic><\/jats:styled-content> gene variation on insulin\u2010stimulated lipid oxidation and neither on the baseline nor on the insulin\u2010stimulated carbohydrate oxidation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data show that this <jats:styled-content style=\"fixed-case\"><jats:italic>FTO<\/jats:italic><\/jats:styled-content> gene variation might influence the baseline lipid oxidation in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients. This might potentially be one of the mechanisms explaining the impact of the <jats:styled-content style=\"fixed-case\"><jats:italic>FTO<\/jats:italic><\/jats:styled-content> gene on body weight in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04379.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T19:49:25Z","timestamp":1330976965000},"page":"120-125","source":"Crossref","is-referenced-by-count":22,"title":["Impact of the <scp><i>FTO<\/i><\/scp> gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"77","author":[{"given":"Irina","family":"Kowalska","sequence":"first","affiliation":[{"name":"Department of Endocrinology Diabetology and Internal Medicine Medical University of Bia\u0142ystok Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Adamska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetology and Internal Medicine Medical University of Bia\u0142ystok Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"T. Malecki","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases Medical College Jagiellonian University Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Karczewska\u2010Kupczewska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetology and Internal Medicine Medical University of Bia\u0142ystok Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Nikolajuk","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetology and Internal Medicine Medical University of Bia\u0142ystok Bia\u0142ystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Szopa","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases Medical College Jagiellonian University Krakow 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