{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:38:04Z","timestamp":1781663884838,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Insulin resistance is a core feature of polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). Recently, genome\u2010wide association studies have reported a number of single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) with reproducible associations and susceptibilities to type 2 diabetes. We examined the potential association between the diabetogenic genes uncovered in the genome\u2010wide association studies and <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Women with or without <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> samples from 377 patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and 386 age\u2010matched controls were genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the 12 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in the six genes (<jats:styled-content style=\"fixed-case\"><jats:italic>KCNJ11<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>TCF7L2<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>SLC30A8<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>HHEX<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>FTO<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>CDKAL1<\/jats:italic><\/jats:styled-content>) uncovered in the genome\u2010wide association studies were associated with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. For further analysis, the patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> were divided into two or three subgroups according to genotype, and the associations between the genotypes and insulin resistance or insulin secretory capacity were assessed. No <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s were significantly associated with <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HOMA<\/jats:styled-content> <jats:sub>\u03b2cell<\/jats:sub> (%), or 2\u2010h 75\u2010g oral glucose tolerance test insulin levels in the patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>; there were no significant associations with other serum hormonal and metabolic markers, such as androgen or glucose levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the six type 2 diabetes\u2013associated genes identified in genome\u2010wide association studies are not associated with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04389.x","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T12:42:54Z","timestamp":1332592974000},"page":"439-445","source":"Crossref","is-referenced-by-count":34,"title":["Polycystic ovary syndrome is not associated with polymorphisms of the <scp><i>TCF7L2<\/i><\/scp>,<scp><i>CDKAL1<\/i><\/scp>,<scp><i>HHEX<\/i><\/scp>,<scp><i>KCNJ11<\/i><\/scp>,<scp><i>FTO<\/i><\/scp> and <scp><i>SLC30A8<\/i><\/scp> genes"],"prefix":"10.1111","volume":"77","author":[{"given":"Jin Ju","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University College of Medicine Seoul Korea"},{"name":"Healthcare System Gangnam Centre Seoul National University Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University College of Medicine Seoul Korea"},{"name":"The Institute of Reproductive Medicine and Population Medical Research Centre Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min A.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Maria Fertility Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Ri","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul Municipal Boramae Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Sik","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine College of Medicine Inha University Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ho","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Graduate School of Medicine Dongguk University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Yong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Seoul National University College of Medicine Seoul Korea"},{"name":"The Institute of Reproductive Medicine and 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