{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:56:48Z","timestamp":1773421008090,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010type natriuretic peptide (<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content>) is a paracrine regulatory factor of the growth plate and plays a key role in endochondral growth. Its amino\u2010terminal propeptide (<jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content>) is an equimolar product of <jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> biosynthesis and is easily measured in plasma. Preliminary studies suggest that <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> levels correlate with height velocity in sheep and children. The objectives of the study were to correlate <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> levels with height velocity and to define the reference range for plasma <jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> across childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a prospective, cross\u2010sectional, observational study of healthy children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Participants were 258 healthy children between 2\u00a0months and 20\u00a0years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Anthropometrics were obtained and <jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> levels were determined by radioimmunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For both sexes, <jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> levels were high in infancy, lower in early childhood, rising during puberty, then falling to low adult levels. Levels of <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> peaked at 14\u00b71\u00a0years in boys and 11\u00b79\u00a0years in girls, coincident with the age of peak height velocity. Levels of <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> varied with pubertal status, peaking at genital Tanner stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> in boys and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> in girls. There was a highly significant correlation between <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> and height velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010type natriuretic peptide plays an integral role in endochondral growth. We show here that <jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> synthesis (as measured by <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> levels in plasma) is closely related to linear growth in healthy children at all ages. We propose <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content>pro<jats:styled-content style=\"fixed-case\">CNP<\/jats:styled-content> as a biomarker of linear growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04392.x","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T22:58:39Z","timestamp":1332457119000},"page":"416-422","source":"Crossref","is-referenced-by-count":49,"title":["Amino\u2010terminal propeptide of <scp>C<\/scp>\u2010type natriuretic peptide (<scp>NT<\/scp>pro<scp>CNP<\/scp>) predicts height velocity in healthy children"],"prefix":"10.1111","volume":"77","author":[{"given":"Robert C.","family":"Olney","sequence":"first","affiliation":[{"name":"Division of Endocrinology Nemours Children's Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph W.","family":"Permuy","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Nemours Children's Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy C. 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