{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:22:28Z","timestamp":1781148148142,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Study objectives<\/jats:title><jats:p>High doses of short\u2010term testosterone have been shown to acutely worsen sleep\u2010disordered breathing in men with obstructive sleep apnoea (<jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>). The effects of lower, near\u2010conventional doses of testosterone in obese men with <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> may differ over the longer term but have not been systematically studied. We assessed sleep and breathing effects of near\u2010conventional testosterone treatment as an adjunct to weight loss in obese men with severe <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>An 18\u2010week randomized, double\u2010blind, placebo\u2010controlled, parallel group trial in 67 men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interventions<\/jats:title><jats:p>All subjects were placed on a hypocaloric diet and then received intramuscular injections of 1000\u00a0mg testosterone undecanoate or placebo at 0, 6 and 12\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and Results<\/jats:title><jats:p>Sleep and breathing were measured by nocturnal polysomnography at 0, 7 and 18\u00a0weeks. Testosterone, compared to placebo, worsened the oxygen desaturation index (<jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>) by 10\u00b73\u00a0events\/h (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0\u00b78\u201319\u00b78\u00a0events\/h; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703) and nocturnal hypoxaemia (sleep time with oxygen saturation &lt;90%, SpO<jats:sub>2<\/jats:sub>T90%) by 6\u00b71% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1\u00b75\u201310\u00b76; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) at 7\u00a0weeks. Testosterone therapy did not alter <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content> (4\u00b75, \u22125\u00b74 to 14\u00b74\u00a0events\/h; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b736) or SpO<jats:sub>2<\/jats:sub>T90% at 18\u00a0weeks (2\u00b79, \u22121\u00b79\u20137\u00b77%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b723) compared to placebo. The testosterone treatment effects on <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content> and SpO<jats:sub>2<\/jats:sub>T90% were not influenced by baseline testosterone concentrations (testosterone by treatment interactions, all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00\u00b735). Blood testosterone concentrations did not correlate with <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content> or SpO<jats:sub>2<\/jats:sub>T90% (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00\u00b719).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Testosterone therapy in obese men with severe <jats:styled-content style=\"fixed-case\">OSA<\/jats:styled-content> mildly worsens sleep\u2010disordered breathing in a time\u2010limited manner, irrespective of initial testosterone concentrations. This time\u2010dependency was not related to testosterone concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial\u00a0Registration<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.anzctr.org.au\">www.anzctr.org.au<\/jats:ext-link> Identifier: ACTRN1260\u20106000404527.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04413.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T13:13:48Z","timestamp":1334754828000},"page":"599-607","source":"Crossref","is-referenced-by-count":97,"title":["Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"77","author":[{"given":"Camilla M.","family":"Hoyos","sequence":"first","affiliation":[{"name":"Endocrine and Cardiometabolic Research Group NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS) Woolcock Institute of Medical Research University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roo","family":"Killick","sequence":"additional","affiliation":[{"name":"Endocrine and Cardiometabolic Research Group NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS) Woolcock Institute of Medical Research University of Sydney Sydney NSW Australia"},{"name":"Royal Prince Alfred Hospital University of Sydney Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon J.","family":"Yee","sequence":"additional","affiliation":[{"name":"Endocrine and Cardiometabolic Research Group NHMRC Centre for Integrated Research and Understanding of Sleep (CIRUS) Woolcock Institute of Medical Research University of Sydney Sydney NSW Australia"},{"name":"Royal Prince Alfred Hospital University of Sydney Sydney NSW Australia"},{"name":"Sleep and Circadian Research Group NHMRC Centre for Integrated Research 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