{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:44:27Z","timestamp":1759333467989},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Oral contraceptive use might be associated with cardiometabolic risk in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. We aimed to compare the effects of ethinyl estradiol\u2013drospirenone (<jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content>) alone <jats:italic>vs <\/jats:italic><jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> plus metformin on clinical and cardiometabolic parameters in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective observational study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Forty\u2010five lean patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> who received <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> (30\u00a0\u03bcg\/3\u00a0mg) (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) or <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> plus metformin (1700\u00a0mg\/day) (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and 45 <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010matched healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, waist\u2010to\u2010hip ratio (<jats:styled-content style=\"fixed-case\">WHR<\/jats:styled-content>), hirsutism scores, androgens, lipids, glucose and insulin levels during an <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> were measured before and after 6\u00a0months of treatment in patients and compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> showed similar glucose, insulin and lipids but increased 2\u00a0h glucose values compared to controls. Hirsutism scores and free androgen index decreased in both treatment groups. <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">WHR<\/jats:styled-content> did not show any change in the <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> group, while metformin addition resulted in a decrease in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. Lipid levels increased in both groups. Glucose and insulin parameters did not change in any group, but metformin addition compared to <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> alone significantly decreased waist circumference, fasting insulin and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>. After\u2010treatment values for both <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> alone and in combination with metformin compared to the control group showed increased 2\u00a0h glucose and increased lipids in patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> alone or in combination with metformin improves clinical and biochemical hyperandrogenism in lean <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. Both treatments similarly alter lipid profile. <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> alone does not affect insulin sensitivity, whereas combining <jats:styled-content style=\"fixed-case\">EE<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DRSP<\/jats:styled-content> with metformin might improve it.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04415.x","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T06:14:43Z","timestamp":1334729683000},"page":"379-384","source":"Crossref","is-referenced-by-count":12,"title":["Ethinyl estradiol\u2013drospirenone <i>vs<\/i> ethinyl estradiol\u2013drospirenone plus metformin in the treatment of lean women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"78","author":[{"given":"Nese","family":"Cinar","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Unit 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