{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:09:32Z","timestamp":1761844172728},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Adult growth hormone deficiency (<jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>) has detrimental effects on metabolic profile, leading to an increased cardiovascular mortality and morbidity. Above all, disturbance in postprandial triglyceride metabolism is of major concern because of the crucial role of triglyceride\u2010rich lipoproteins in atherogenesis. The majority of previous studies on <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement have shown favourable changes in the fasting lipid profile. Aim of this study is to investigate whether this beneficial effect is exerted also on postprandial triglyceride (<jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>) metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We challenged nine <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> patients with a standardized fat loading meal at baseline and after 6\u00a0months of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> replacement therapy. Nine healthy control subjects were similarly tested under baseline conditions. Blood samples were obtained before and up to 8\u00a0h after fat loading for serum lipid analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> patients with fasting <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> level in the normal range (1\u00b729\u00a0\u00b1\u00a00\u00b731\u00a0m<jats:sc>m<\/jats:sc>) had a delayed postprandial <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content> clearance compared to healthy controls (triglyceride level at 8\u00a0h, 3\u00b782\u00a0\u00b1\u00a00\u00b783 <jats:italic>vs<\/jats:italic> 1\u00a0\u00b1\u00a00\u00b706\u00a0m<jats:sc>m <\/jats:sc><jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701), and the postprandial hypertriglyceridaemia was not corrected by 6\u00a0months of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study has shown for the first time that <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> adult patients have a higher postprandial triglyceridaemia compared to healthy controls when challenged by a standardized fat load and that this atherogenic feature is not normalized by short\u2010term <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> treatment despite a decrease in visceral fat mass described during the replacement therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04416.x","type":"journal-article","created":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T14:45:38Z","timestamp":1334933138000},"page":"721-727","source":"Crossref","is-referenced-by-count":2,"title":["Postprandial triglyceride profile after a standardized oral fat load is altered in growth hormone (<scp>GH<\/scp>)\u2010deficient adult patients and is not improved after 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