{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:34:14Z","timestamp":1768926854771,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Puberty is a period characterized by growth spurt and rapid change in body composition. The effect of Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist therapy for central precocious puberty on bone mineral density is unclear. We demonstrated changes in bone mineral density in subjects with central precocious puberty, who were treated with Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist for more than 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The changes in bone mineral density and body compositions were tested with analysis of variance with repeated measures to identify statistical significance over the treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>One hundred ninety\u2010five Korean girls with central precocious puberty were treated with Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist, and among these subjects, 39 patients were treated for more than 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Dual\u2010energy X\u2010ray absorptiometry was performed on the subjects at the initial evaluation and once yearly thereafter while on the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The bone mineral density parameters for chronological age tended to decrease near the mean for the treatment period; however, they increased significantly for bone age excluding bone mineral apparent density. An increment of the <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> was not significant for the chronological age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Three\u2010year treatment with Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist in central precocious puberty patients did not impair bone maturation. Gn<jats:styled-content style=\"fixed-case\">RH<\/jats:styled-content> agonist could be effectively commenced in girls with precocious puberty from an early age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04418.x","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T10:38:13Z","timestamp":1335350293000},"page":"743-748","source":"Crossref","is-referenced-by-count":29,"title":["The effect of gonadotrophin\u2010releasing hormone agonist treatment over 3\u00a0years on bone mineral density and body composition in girls with central precocious puberty"],"prefix":"10.1111","volume":"77","author":[{"given":"Hong K.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics Ajou University Hospital School of Medicine Ajou University Suwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ajou University 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