{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:40:21Z","timestamp":1759178421970},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed at quantifying the associations between high\u2010sensitivity C\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and forearm bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) throughout adolescence in overweight and normal\u2010weight girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>346 girls born in 1990 and attending schools in Porto, Portugal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Adolescents were evaluated at 13 and 17\u00a0years of age using a standard protocol. Forearm <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was measured by dual\u2010energy X\u2010ray absorptiometry. Anthropometric assessment included weight, height, body fat percentage and waist circumference. Girls were categorized according to age\u2010 and sex\u2010specific body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) percentiles as normal weight in both evaluations or overweight in at least one assessment. Pubertal development was estimated using menarche age. Serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was determined using particle\u2010enhanced immunonephelometry. Hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was log\u2010transformed, and associations were quantified using linear regression coefficients and 95% confidence intervals (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An inverse association between hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was observed from 13\u00a0years of age in overweight girls [\u221211\u00b726\u00a0mg\/cm<jats:sup>2<\/jats:sup> (\u221221\u00b799, \u22120\u00b752)]. Among normal\u2010weight adolescents, 13\u2010year\u2010old hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> was negatively associated with prospective <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> variation between 13 and 17\u00a0years of age [\u22121\u00b790\u00a0mg\/cm<jats:sup>2<\/jats:sup>\u00a0year (\u22123\u00b735, \u22120\u00b745)]. Overweight girls who maintained higher levels of hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> throughout adolescence had lower 17\u2010year\u2010old <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> (adjusted mean 0\u00b7441 <jats:italic>vs<\/jats:italic> 0\u00b7483\u00a0g\/cm<jats:sup>2<\/jats:sup> in those who remained with lower levels of hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>). At 17\u00a0years of age, significant inverse associations were found between hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> among normal\u2010weight and overweight girls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obesity\u2010related early systemic inflammation might be involved in suboptimal bone accrual, particularly in overweight girls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04430.x","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T12:07:34Z","timestamp":1336651654000},"page":"665-671","source":"Crossref","is-referenced-by-count":12,"title":["Low\u2010grade systemic inflammation and suboptimal bone mineral density throughout adolescence: a prospective study in 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