{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:46:52Z","timestamp":1780339612290,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Polycystic ovary syndrome (PCOS<\/jats:styled-content>) is a heterogeneous clinical condition. Oral contraceptive pills (OCP<\/jats:styled-content>s) have conventionally been the mainstay of treatment for the amelioration of hyperandrogenism and regulation of menstrual cycles in women with PCOS<\/jats:styled-content>. Metformin has beneficial effects on insulin resistance and endothelial functions. To our knowledge, the effect of metformin\/OCP<\/jats:styled-content> combination treatment on aortic stiffness has not been studied so far.<\/jats:p><\/jats:sec>Objective<\/jats:title>The aim of this study was to investigate the effects of treatment with drospirenone\/ethinyl oestradiol (E<\/jats:styled-content>\/E<\/jats:styled-content>) alone or in combination with metformin on the elastic properties of the aorta in women with PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty\u2010seven women with PCOS<\/jats:styled-content> were enrolled in the study. The first treatment arm, which was treated with OCP<\/jats:styled-content> alone, was described as the OCP<\/jats:styled-content> group (19 patients, mean age: 23\u00b72\u00a0\u00b1\u00a05\u00b74); the other treatment arm, which was treated with OCP<\/jats:styled-content> and metformin, was described as the combination group (18 patients, mean age: 23\u00b70\u00a0\u00b1\u00a04\u00b75). The elastic parameters of the aorta namely \u2018aortic strain\u2019, \u2018aortic distensibility\u2019, \u2018aortic diameter alteration\u2019 and \u2018aortic stiffness index\u2019 were calculated by the appropriate formulae. The hormonal profile, HOMA<\/jats:styled-content>\u2010IR<\/jats:styled-content> score, basal insulin and glucose levels were studied in both groups. Before and after 6\u00a0months of treatment, echocardiographic measurements and laboratory tests were also obtained.<\/jats:p><\/jats:sec>Results<\/jats:title>After 6\u00a0months of treatment, significant weight loss and decrease in body mass index (BMI<\/jats:styled-content>) were observed in the combination group (75\u00b73\u00a0\u00b1\u00a013\u00b73\u00a0kg to 72\u00b73\u00a0\u00b1\u00a013\u00b75\u00a0kg and 31\u00b77\u00a0\u00b1\u00a07\u00b73\u00a0kg\/m\u00b2 vs<\/jats:italic> 30\u00b74\u00a0\u00b1\u00a07\u00b73\u00a0kg\/m\u00b2, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7001 and P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7001, respectively). Conversely in the OCP<\/jats:styled-content> group, BMI<\/jats:styled-content> and weight were not significantly different after 6\u00a0months of treatment (68\u00b78\u00a0\u00b1\u00a018\u00b73\u00a0kg to 71\u00b76\u00a0\u00b1\u00a021\u00b72\u00a0kg and 26\u00b74\u00a0\u00b1\u00a06\u00b72\u00a0kg\/m\u00b2 to 27\u00b74\u00a0\u00b1\u00a06\u00b79\u00a0kg\/m\u00b2, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7159 and P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7149, respectively). In addition, there were no significant differences in aortic strain, distensibility (7\u00b77\u00a0\u00b1\u00a04\u00b72 to 7\u00b78\u00a0\u00b1\u00a03\u00b76 and 7\u00b72\u00a0\u00b1\u00a04\u00b71 to 7\u00b77\u00a0\u00b1\u00a03\u00b76, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7926 and P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7593, respectively) and stiffness index in the OCP<\/jats:styled-content> group (8\u00b78\u00a0\u00b1\u00a07\u00b74 to 8\u00b72\u00a0\u00b1\u00a06\u00b77, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7772). However, in the combination group, the adjusted values of the aortic stiffness index decreased significantly at the 6\u00a0months' follow\u2010up (10\u00b70\u00a0\u00b1\u00a01\u00b75 to 6\u00b77\u00a0\u00b1\u00a00\u00b73, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7021) and aortic distensibility and strain increased but not significantly (7\u00b70\u00a0\u00b1\u00a04\u00b73 to 9\u00b73\u00a0\u00b1\u00a03\u00b73 and 6\u00b78\u00a0\u00b1\u00a03\u00b79 to 9\u00b74\u00a0\u00b1\u00a03\u00b75, P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7163 and P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7071, respectively) at the 6\u00a0months' follow\u2010up.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We demonstrated an improvement in the elastic parameters of the aorta by adding metformin to OCP<\/jats:styled-content> treatment. We suggest that metformin plus OCP<\/jats:styled-content> treatment may decrease cardiovascular disease risk in women with PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04436.x","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T14:52:55Z","timestamp":1336402375000},"page":"885-892","source":"Crossref","is-referenced-by-count":15,"title":["The effects of treatment with drospirenone\/ethinyl oestradiol alone or in combination with metformin on elastic properties of aorta in women with polycystic ovary syndrome"],"prefix":"10.1111","volume":"77","author":[{"given":"Mehmet G.","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Cardiology School of Medicine Erciyes University Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekir","family":"Calapkorur","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine Erciyes University 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