{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:12Z","timestamp":1787014452583,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To examine the impact of surgical normalization of testosterone on body weight and on glucose and lipid metabolism and insulin sensitivity in a group of hyperandrogenic women with ovarian androgen\u2010secreting tumours (\n                      <jats:styled-content style=\"fixed-case\">OAST<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Five consecutive postmenopausal hyperandrogenic patients (aged 63\u00a0\u00b1\u00a05\u00a0years) with a diagnosis of\n                      <jats:styled-content style=\"fixed-case\">OAST<\/jats:styled-content>\n                      were prospectively evaluated. Clinical signs, symptoms and metabolic and hormonal parameters were collected at the time of the diagnosis and at follow\u2010up, 12\u00a0months after surgical oophorectomy. A group of 15 age\u2010matched and body mass index\u2010matched postmenopausal control women served as a reference group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, patients with\n                      <jats:styled-content style=\"fixed-case\">OAST<\/jats:styled-content>\n                      had very high testosterone levels and inappropriately low gonadotrophin levels for their menopausal status. All the women were overweight or obese, and one had a history of polycystic ovary syndrome and Type 2 diabetes. Twelve months after surgical oophorectomy, testosterone and gonadotrophin levels returned to appropriate values for menopausal status in all patients; however, no change in body weight was found. Fasting glucose levels slightly increased (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00\u00b705) without any significant change in other metabolic parameters. In the woman with diabetes, a moderate decrease in haemoglobin A1c occurred. Red blood cell count and haematocrit values were normalized (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00\u00b705, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Normalization of androgen levels achieved after surgical oophorectomy did not cause any significant change in body weight and insulin sensitivity. These findings may offer a different perspective on the impact of hyperandrogenaemia on metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04438.x","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T14:39:38Z","timestamp":1337006378000},"page":"533-538","source":"Crossref","is-referenced-by-count":18,"title":["No metabolic impact of surgical normalization of hyperandrogenism in postmenopausal women with ovarian androgen\u2010secreting tumours"],"prefix":"10.1111","volume":"78","author":[{"given":"Carla","family":"Pelusi","sequence":"first","affiliation":[{"name":"Division of Endocrinology S. Orsola\u2010Malpighi Hospital, University Alma Mater Studiorum Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Forlani","sequence":"additional","affiliation":[{"name":"Division of Endocrinology S. Orsola\u2010Malpighi Hospital, University Alma Mater Studiorum Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Zanotti","sequence":"additional","affiliation":[{"name":"Division of Endocrinology S. Orsola\u2010Malpighi Hospital, University Alma Mater Studiorum Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gambineri","sequence":"additional","affiliation":[{"name":"Division of Endocrinology S. Orsola\u2010Malpighi Hospital, University Alma Mater Studiorum Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Division of Endocrinology S. Orsola\u2010Malpighi Hospital, University Alma Mater Studiorum Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30244-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-179-6_6"},{"key":"e_1_2_6_4_1","first-page":"161","article-title":"Differential diagnosis of ovarian tumors based primarily on their patterns and cell types","volume":"18","author":"Young R.H.","year":"2001","journal-title":"Seminars in Diagnostic Pathology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.521263"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-007-1032-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32832afd4d"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.7.3115"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.07070"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.259.4.E555"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2250"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi054"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/2000-1967-068"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225351"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-21-11-1440"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archderm.1977.01640010111023","article-title":"Androgenetic alopecia","volume":"113","author":"Ludwig E.","year":"1977","journal-title":"Archives of Dermatology"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-2437"},{"key":"e_1_2_6_18_1","first-page":"1","volume-title":"Obesity: Preventing and Managing the Global Epidemic, Report of a World Health Organization Consultation on Obesity","author":"World Health Organization","year":"2000"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.6079"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb38738.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-1-3"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.774"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.10.054"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2724"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1324-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)49211-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/oxfordjournals.humrep.a137058","article-title":"Insulin secretion in polycystic ovarian disease: effect of ovarian suppression by GnRH agonist","volume":"5","author":"Lanzone A.","year":"1990","journal-title":"Human Reproduction"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590400004736"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077827"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01753.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00909.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01912.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.03.048"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.42"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.013"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2108"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2012.04438.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2012.04438.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T06:08:48Z","timestamp":1700633328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2012.04438.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1365-2265.2012.04438.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2012.04438.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,12]]}}}