{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:19:04Z","timestamp":1783477144929,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Previous studies of the current iodine status in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkey have yielded contradictory results. Although urinary iodine concentration (<jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content>) in school age children (<jats:styled-content style=\"fixed-case\">SAC<\/jats:styled-content>) suggests sufficient iodine status, studies on neonatal thyroid\u2010stimulating hormone (<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>) indicate that iodine deficiency is a continuing problem. We aimed to assess the iodine nutritional status of pregnant women living in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nkara, an area that has appeared to be iodine sufficient in earlier studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Hospital\u2010based, noninterventional, prospective, cross\u2010sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 162 pregnant women in their second trimester were examined regarding iodized salt use, <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content>, presence or absence of goitre and thyroid function. Goitre status was determined by palpation. <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> was measured using colorimetric method based on <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>andell\u2013<jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>olthoff reaction. Thyroid hormones and <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> were measured by chemiluminescence immunoassays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While the proportion of iodized salt use was 80\u00b72%, <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> was below 150\u00a0\u03bcg\/l in 72\u00b78% of the women. The median <jats:styled-content style=\"fixed-case\">UIC<\/jats:styled-content> was 80\u00b75 (8\u00b79\u2013340\u00b73)\u00a0\u03bcg\/l, indicating insufficient iodine intake. Total goitre rate was 15\u00b74%. Preferential T3 secretion reflected by elevated molar ratios of <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>3\/<jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 was present in 89\u00b75% of the women. 12\u00b74% had subclinical hypothyroidism or isolated hypothyroxinaemia based on serum <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content>4 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that iodine deficiency is a serious problem among pregnant women in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>nkara. These data confirm that iodine nutritional status among <jats:styled-content style=\"fixed-case\">SAC<\/jats:styled-content> does not reflect the iodine supply for pregnant women. We propose that nationwide surveillance studies should urgently be performed to directly assess and monitor the iodine status of pregnant women. We also consider that pregnant women in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkey should be supplemented by iodine\u2010containing preparations in addition to iodized salt.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04440.x","type":"journal-article","created":{"date-parts":[[2012,5,15]],"date-time":"2012-05-15T14:45:35Z","timestamp":1337093135000},"page":"615-620","source":"Crossref","is-referenced-by-count":21,"title":["Iodine deficiency in pregnant women in the apparently iodine\u2010sufficient capital city of <scp>T<\/scp>urkey"],"prefix":"10.1111","volume":"77","author":[{"given":"Alev","family":"Oguz Kutlu","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology Dr. Sami Ulus Women's and Children's Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cengiz","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Ondokuz Mayis 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