{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:34:06Z","timestamp":1793223246355,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T00:00:00Z","timestamp":1352419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Foetal exposure to high testosterone concentrations seems to be involved in the development of mammalian brain and related to pervasive developmental disorders (PDD<\/jats:styled-content>s). The aim of the current study was to test the hypothesis that children born from hyperandrogenic women with polycystic ovary syndrome (PCOS<\/jats:styled-content>) are at higher risk of PDD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Design<\/jats:title>Longitudinal case\u2013control study.<\/jats:p><\/jats:sec>Patients<\/jats:title>Thirty pregnant PCOS<\/jats:styled-content> patients with hyperandrogenaemia and other 45 pregnant healthy women were followed during pregnancy. All women had a healthy baby.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Clinical evaluations and biochemical assays of the mothers during pregnancy and after delivery were performed. The children's versions of the A<\/jats:styled-content>utism\u2010S<\/jats:styled-content>pectrum Q<\/jats:styled-content>uotient (AQ<\/jats:styled-content>\u2010C<\/jats:styled-content>), the E<\/jats:styled-content>mpathy Q<\/jats:styled-content>uotient (EQ<\/jats:styled-content>\u2010C<\/jats:styled-content>) and S<\/jats:styled-content>ystemizing Q<\/jats:styled-content>uotient (SQ<\/jats:styled-content>\u2010C<\/jats:styled-content>) tests were administered.<\/jats:p><\/jats:sec>Results<\/jats:title>Total AQ<\/jats:styled-content>\u2010C<\/jats:styled-content> and communication scores were significantly higher for children of PCOS<\/jats:styled-content> patients. Stratifying our population according to sex, total AQ<\/jats:styled-content>\u2010C<\/jats:styled-content>, communication and attention switching subscores were significantly higher only for daughters of PCOS<\/jats:styled-content> patients. EQ<\/jats:styled-content>\u2010C<\/jats:styled-content> and SQ<\/jats:styled-content>\u2010C<\/jats:styled-content> scores resulted in significantly lower and higher scores, respectively, only in daughters of PCOS<\/jats:styled-content> patients in comparison with those of healthy non\u2010PCOS<\/jats:styled-content> controls. AQ<\/jats:styled-content>\u2010C<\/jats:styled-content>, EQ<\/jats:styled-content>\u2010C and SQ<\/jats:styled-content>\u2010C<\/jats:styled-content> scores, irrespective of the studied group and\/or subclassification by gender, were significantly influenced by amniotic testosterone levels.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Daughters of mothers affected by hyperandrogenic PCOS<\/jats:styled-content> seem to have a higher risk for PDD<\/jats:styled-content>s probably due to an unbalanced prenatal exposure to high levels of testosterone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04443.x","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T15:15:52Z","timestamp":1337613352000},"page":"898-904","source":"Crossref","is-referenced-by-count":124,"title":["Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case\u2013control 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