{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:41:11Z","timestamp":1777650071387,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The hormone adiponectin (<jats:styled-content style=\"fixed-case\">APN<\/jats:styled-content>) circulates in plasma as various multimeric complexes. The high\u2010molecular\u2010weight (<jats:styled-content style=\"fixed-case\">HMW<\/jats:styled-content>) isoform has been reported to exert the most favourable metabolic regulatory and vasculoprotective effects. This study determined the circulatory distribution of <jats:styled-content style=\"fixed-case\">APN<\/jats:styled-content> multimers and their relationships with cardiovascular disease (<jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>)\u2010related biochemical indicators in patients with hypercholesterolaemia (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 148 male age\u2010 and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010matched patients with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> (80 with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> and 68 without <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>) and 84 male healthy controls were enrolled. Diabetes mellitus, hypertension, nephropathy and cigarette use constituted exclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">HMW<\/jats:styled-content> and medium\u2010molecular\u2010weight (<jats:styled-content style=\"fixed-case\">MMW<\/jats:styled-content>) forms of <jats:styled-content style=\"fixed-case\">APN<\/jats:styled-content> were significantly increased in <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> without <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HMW<\/jats:styled-content>: 4\u00b798\u00a0\u00b1\u00a00\u00b787 <jats:italic>vs<\/jats:italic> 2\u00b751\u00a0\u00b1\u00a00\u00b733 in control, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701; <jats:styled-content style=\"fixed-case\">MMW<\/jats:styled-content>: 2\u00b720\u00a0\u00b1\u00a00\u00b736 <jats:italic>vs<\/jats:italic> 1\u00b701\u00a0\u00b1\u00a00\u00b715 in control, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701) and were comparable to control in patients with hypercholesterolaemia with <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HCVD<\/jats:styled-content>). In comparison with other <jats:styled-content style=\"fixed-case\">APN<\/jats:styled-content> oligomers, <jats:styled-content style=\"fixed-case\">HMW<\/jats:styled-content> is most closely associated with the <jats:styled-content style=\"fixed-case\">HCVD<\/jats:styled-content>\u2010related biochemical factors, total cholesterol (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7345, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705), high\u2010density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>c, <jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7325, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b705) and uric acid (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>,<jats:italic> r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>\u22120\u00b7472, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701). Additional analysis via binary logistic regression suggests that <jats:styled-content style=\"fixed-case\">HMW<\/jats:styled-content> is an independent predictor of risk of <jats:styled-content style=\"fixed-case\">HCVD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 8\u00b7434; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that reduced <jats:styled-content style=\"fixed-case\">HMW<\/jats:styled-content> isoform concentrations might be considered as an independent risk factor for cardiovascular complications in patients with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04444.x","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T07:07:40Z","timestamp":1337670460000},"page":"539-544","source":"Crossref","is-referenced-by-count":8,"title":["Reduced high\u2010molecular\u2010weight adiponectin is an independent risk factor for cardiovascular lesions in hypercholesterolaemic patients"],"prefix":"10.1111","volume":"78","author":[{"given":"Wenqing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Tangdu Hospital the Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Physiology the Fourth Military Medical University Xi'an 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