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Published data on the quality of life (<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) of patients with <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content> are scarce and conflicting. In view of the discordant findings and the advances in the management of these subjects, we aimed to evaluate the <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content> followed up in a tertiary endocrine <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>All consecutive patients with <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content> attending the outpatient clinic in the Department of Endocrinology in Oxford over a 6\u2010month period (<jats:italic>n<\/jats:italic>\u00a0=\u00a0193) were offered 3 health\u2010related <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> questionnaires [Short Form 36 (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>36), Nottingham Health Profile (<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>), European Quality of Life Scale (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uro<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>)] to complete. Patient outcomes (response rate 93\u00b73%) were compared with age\u2010related <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> reference values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> scores in the <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 or the 5 dimensions of health in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uro<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> was different from the reference values. The visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) score (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uro<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) was slightly compromised (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b7041). In the <jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content> questionnaire, males had no parameter significantly affected, whereas females performed worse in 1\/6 areas (energy levels). Tumour recurrence was an independent predictor for compromised <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score and for anxiety\/depression (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uro<jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>), and visual field defects for more frequent problems with interests\/hobbies (<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, the health\u2010related <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content> and perception of subjective health in patients with <jats:styled-content style=\"fixed-case\">NFA<\/jats:styled-content> was not compromised to any major extent suggesting that we can now offer the prospect of treatment and replacement, which will provide a normal or near\u2010normal <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>o<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>. Specific groups are affected in various dimensions, necessitating measures to compensate for predisposing factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04449.x","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T09:30:08Z","timestamp":1338283808000},"page":"86-93","source":"Crossref","is-referenced-by-count":39,"title":["Current treatment protocols can offer a normal or near\u2010normal quality of life in the majority of patients with non\u2010functioning pituitary adenomas"],"prefix":"10.1111","volume":"78","author":[{"given":"Cristina","family":"Capatina","sequence":"first","affiliation":[{"name":"Department of Endocrinology Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Christodoulides","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Cudlip","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley B.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A. 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