{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T12:47:12Z","timestamp":1783774032759,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite ample experience with surgical treatment of nonfunctioning pituitary adenomas, objective data defining the risk for visual compromise depending on the suprasellar extension in pituitary adenomas are sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>We measured the suprasellar extension of 98 newly diagnosed suprasellar nonfunctioning pituitary adenomas on sagittal and coronal magnetic resonance images using reference lines for the skull base level. In addition, the position of the optic chiasm in relation to the suprasellar adenoma was assessed. The findings were correlated with the degree of visual dysfunction and with the type of visual field defects (<jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy per cent of the patients suffered from <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content>. The most frequent perimetric findings were bilateral (81\u00b72%) or unilateral (10\u00b71%) temporal hemifield defects. For the coronal view, a suprasellar extension of 12\u00a0mm was a practicable cut\u2010off value for emergence of visual disturbances (87\u00b70% sensitivity, 72\u00b74% specificity). For the sagittal view, 8\u2010mm suprasellar extension was a suitable cut\u2010off for appearance of chiasma syndrome (87\u00b70% sensitivity, 75\u00b79% specificity). In five of seven cases without a chiasma syndrome despite a suprasellar extension &gt;12 (coronal) and 8\u00a0mm (sagittal), the optic chiasm was found in an anterior position. No correlation was found between the position of the chiasm (i.e. anterior, superior or posterior) and the type of <jats:styled-content style=\"fixed-case\">VFD<\/jats:styled-content> (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0=\u00a00\u00b7647). A highly significant correlation was found between the decline of visual acuity and the suprasellar adenoma extension (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content><\/jats:italic>\u00a0&lt;\u00a00\u00b70001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cut\u2010off values possess a high sensitivity and specificity for imminent visual disturbances and are helpful for clinical decision\u2010making. A delayed emergence of visual dysfunction may be observed with an anterior position of the optic chiasm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04457.x","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T06:09:20Z","timestamp":1341295760000},"page":"728-734","source":"Crossref","is-referenced-by-count":44,"title":["Predictors for visual dysfunction in nonfunctioning pituitary adenomas \u2013 implications for neurosurgical management"],"prefix":"10.1111","volume":"77","author":[{"given":"Kathrin","family":"Schmalisch","sequence":"first","affiliation":[{"name":"Department of Neurosurgery University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Milian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thilo","family":"Schimitzek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf A.","family":"Lagr\u00e8ze","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Honegger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.05.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.6.9s.S23"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-1108-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02688690120114192"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb01031.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-004-0863-5"},{"key":"e_1_2_7_8_1","first-page":"559","article-title":"Chiasmal syndrome","volume":"66","author":"Trevino R.","year":"1995","journal-title":"Journal of the American Optometric Association"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02334"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700165"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01401176"},{"key":"e_1_2_7_12_1","first-page":"127","article-title":"Visual field defects in non\u2010functioning pituitary adenomas","volume":"50","author":"Thomas R.","year":"2002","journal-title":"Indian Journal of Ophthalmology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1990.11739907"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198509000-00008"},{"key":"e_1_2_7_15_1","first-page":"262","article-title":"Visual outcomes of pituitary adenoma surgery","volume":"11","author":"Sullivan J.L.","year":"1991","journal-title":"Journal of Clinical Neuro\u2010Ophthalmology"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2012.04457.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2012.04457.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:03:21Z","timestamp":1695485001000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2012.04457.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-2265.2012.04457.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2012.04457.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,5]]}}}