{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:58:12Z","timestamp":1789534692741,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Thymic neuroendocrine tumour (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>) occurs in 2\u20135% of patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 and has high malignant potency accompanying recurrence and distant metastasis. While <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> is recognized to develop predominantly in men and heavy smokers, a number of female patients have been reported in the literature. The objective of this study is to clarify the clinical features of <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> using database analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Patients<\/jats:title><jats:p>Clinical data of patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> were extracted and analysed from a recently constructed database of <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 560 registered cases, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> was seen in 28 (5\u00b70%) patients. Of note, 36% of patients (10\/28) were women; only one patient among those was a smoker and another six patients were non\u2010smokers. Age at diagnosis of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1, tumour size, prevalence of other <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1\u2010related tumours did not differ between male and female patients, and 10\u2010year survival probability was 0\u00b7271\u00a0\u00b1\u00a00\u00b7106.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the prevalence of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> in women (3\u00b72%) is significantly lower than that in men (7\u00b76%), a considerable proportion of female patients develop <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>. Given that <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> is a major determinant of life expectancy of patients, our results alert clinicians who treat patients with <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>1 that surveillance of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content> is essential even for female patients without a smoking habit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04467.x","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T06:13:06Z","timestamp":1339567986000},"page":"248-254","source":"Crossref","is-referenced-by-count":26,"title":["Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare 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