{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:03:54Z","timestamp":1783487034586,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A thyrotropin(<jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>)\u2010lowering effect of metformin therapy has been recently reported in patients with type 2 diabetes (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>) and hypothyroidism. We aimed to evaluate the interplay between metformin therapy and serum <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> concentrations in a group of patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2D and normal thyroid function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Eight hundred and twenty\u2010eight euthyroid patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (53% women, mean age 65\u00b79\u00a0years, median duration of diabetes 10\u00a0years) were retrospectively evaluated. There were 250 patients on metformin treatment (30\u00b72%). Serum concentrations of <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> were measured in all subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients on metformin treatment exhibited significantly higher <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels [1\u00b763 (1\u00b711\u20132\u00b724)\u00a0<jats:styled-content style=\"fixed-case\">mU<\/jats:styled-content>\/l] than those found in patients without metformin [1\u00b740 (1\u00b701\u20132\u00b724)\u00a0<jats:styled-content style=\"fixed-case\">mU<\/jats:styled-content>\/l, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009]. We found no significant differences in <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> levels in patients who were on therapy with other oral antidiabetics, antihypertensive drugs or hypolipidemic agents in relation to subjects not taking these drugs. Serum <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> was significantly related to gender, body mass index, hyperlipidaemia and the presence of goitre and diabetic macroangiopathy. In multiple regression analysis with <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> as dependent variable, goitre was negatively related to TSH values. Metformin therapy was a nonsignificant variable in this model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, this is the first survey analysing the relationship between metformin and thyroid function in a large cohort of patients with diabetes. Our data do not support the presence of an independent and significant relationship between <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> values and metformin treatment in euthyroid patients with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04468.x","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T06:23:28Z","timestamp":1339482208000},"page":"505-511","source":"Crossref","is-referenced-by-count":38,"title":["Relationship between serum thyrotropin concentrations and metformin therapy in euthyroid patients with type 2 diabetes"],"prefix":"10.1111","volume":"78","author":[{"given":"Juan J.","family":"D\u00edez","sequence":"first","affiliation":[{"name":"Department of Endocrinology Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hospital Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(68)90136-4"},{"key":"e_1_2_6_3_1","first-page":"638","article-title":"Hypothyroidism and diabetes mellitus in an American Indian population","volume":"49","author":"Michalek A.M.","year":"2000","journal-title":"Journal of Family Practice"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2004.14.853"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1995.tb00553.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02246.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1157-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528070-00004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1210"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-007-9012-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0273"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464\u20105491.2012.03687.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010012\u20109621\u20103"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0734"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265133"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-011-0410-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1271691"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350893"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04042.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13505"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3480607"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04058.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2265.2012.04468.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2265.2012.04468.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:08:17Z","timestamp":1700651297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2265.2012.04468.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,12]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1365-2265.2012.04468.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2265.2012.04468.x","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,12]]}}}