{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:11:26Z","timestamp":1790665886722,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:00:00Z","timestamp":1355184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>The effect of dysglycaemia on bone mineral density (BMD<\/jats:styled-content>) has not been studied in young people with CF<\/jats:styled-content>. We examined factors associated with BMD<\/jats:styled-content> in a tertiary paediatric CF<\/jats:styled-content> clinic.<\/jats:p><\/jats:sec>Design<\/jats:title>Retrospective, clinic\u2010based study at The C<\/jats:styled-content>hildren's H<\/jats:styled-content>ospital at W<\/jats:styled-content>estmead, S<\/jats:styled-content>ydney.<\/jats:p><\/jats:sec>Patients<\/jats:title>Young people with CF<\/jats:styled-content> aged \u226418\u00a0years.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Bone mineral density was measured by dual\u2010energy X<\/jats:styled-content>\u2010ray absorptiometry; main outcome measures were total body (TB<\/jats:styled-content>), lumbar spine (LS<\/jats:styled-content>) and femoral neck (FN<\/jats:styled-content>) BMD<\/jats:styled-content> and bone mineral content (BMC<\/jats:styled-content>), and LS<\/jats:styled-content> volumetric BMD<\/jats:styled-content> (vBMD<\/jats:styled-content>), reported as z<\/jats:italic> scores for height. Dysglycaemia, based on oral glucose tolerance test, was defined as CF<\/jats:styled-content>\u2010related diabetes (CFRD<\/jats:styled-content>) or impaired glucose tolerance (IGT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Overall, 14 of 81 (17%) had CFRD<\/jats:styled-content>, 6 (7%) IGT<\/jats:styled-content> and 61 (76%) normal glucose tolerance (NGT<\/jats:styled-content>). Mean age was 14\u00b79\u00a0\u00b1 2\u00b74\u00a0years and mean height z<\/jats:italic> score \u22120\u00b768\u00a0\u00b1\u00a01\u00b739. Osteopenic (z<\/jats:italic> score \u2264\u22122) TB<\/jats:styled-content>, LS<\/jats:styled-content> or FN BMD<\/jats:styled-content> was present in 30 of 81 (37%), BMC<\/jats:styled-content> in 42 (52%) and vBMD<\/jats:styled-content> in 10 (5%). Across the three groups, there were differences in LS<\/jats:styled-content> vBMD<\/jats:styled-content> (CFRD<\/jats:styled-content>, \u22120\u00b767\u00a0\u00b1 0\u00b776; IGT<\/jats:styled-content>, \u22120\u00b752\u00a0\u00b1\u00a00\u00b776; NGT<\/jats:styled-content>, \u22120\u00b705\u00a0\u00b1\u00a01\u00b739; P<\/jats:italic> = 0\u00b704), LS BMD<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b701), LS BMC<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b701) and TB BMD<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b701). In multivariate linear regression, LS BMC<\/jats:styled-content> was associated with dysglycaemia (\u03b2\u00a0=\u00a00\u00b756; 95% CI<\/jats:styled-content>, 0\u00b700\u20131\u00b713; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b705) and approached significance for FEV<\/jats:styled-content>1<\/jats:sub> (\u03b2\u00a0=\u00a00\u00b701; 95% CI<\/jats:styled-content>, 0\u00b700\u20130\u00b702; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b706).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Dysglycaemia is associated with reduced bone mass accrual in youth with CF<\/jats:styled-content>, in addition to recognized factors such as abnormal lung function, poor nutritional status and disease severity. Bone health assessment is essential in youth with CF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04484.x","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T12:57:14Z","timestamp":1341320234000},"page":"36-42","source":"Crossref","is-referenced-by-count":27,"title":["The impact of dysglycaemia on bone mineral accrual in young people with cystic fibrosis"],"prefix":"10.1111","volume":"78","author":[{"given":"Malay","family":"Rana","sequence":"first","affiliation":[{"name":"Institute of Endocrinology and Diabetes Sydney Children's Hospital Network Westmead Australia"},{"name":"School of Women's and Children's Health University of New South Wales Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig F.","family":"Munns","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Diabetes Sydney Children's Hospital Network Westmead Australia"},{"name":"Discipline of 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