{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:54:01Z","timestamp":1787165641617,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      It is not known if endothelial dysfunction, an important early event in the pathogenesis of atherosclerosis, is present in mild primary hyperparathyroidism (\n                      <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>\n                      ) and if so, whether it improves following parathyroidectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      We measured flow\u2010mediated vasodilation (\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      ), which estimates endothelial function by ultrasound imaging, in patients prior to and 6 and 12\u00a0months after parathyroidectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five patients with mild\n                      <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>\n                      [80% female, 61\u00a0\u00b1\u00a01 (mean\u00a0\u00b1\u00a0\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      ) years, serum calcium 2\u00b765\u00a0\u00b1\u00a00\u00b703\u00a0m\n                      <jats:sc>m<\/jats:sc>\n                      (10\u00b76\u00a0\u00b1\u00a00\u00b71\u00a0mg\/dl),\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      10\u00b75\u00a0\u00b1\u00a00\u00b77\u00a0p\n                      <jats:sc>m<\/jats:sc>\n                      (99\u00a0\u00b1\u00a07\u00a0pg\/ml), 25\u2010hydroxyvitamin\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      (25\n                      <jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>\n                      ) 70\u00b73\u00a0\u00b1\u00a03\u00b77\u00a0n\n                      <jats:sc>m<\/jats:sc>\n                      (28\u00b72\u00a0\u00b1\u00a01\u00b75\u00a0ng\/ml)] were studied. Baseline\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      was normal (4\u00b763\u00a0\u00b1\u00a00\u00b751%; reference mean: 4\u00b74\u00a0\u00b1\u00a00\u00b71%) and was not associated with serum calcium,\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      or 25\n                      <jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>\n                      levels. In the group as a whole,\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      did not change after surgery (6\u00a0months: 4\u00b738\u00a0\u00b1\u00a00\u00b783%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b772; 12 months: 5\u00b707\u00a0\u00b1\u00a00\u00b774%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b749). However, in those with abnormal baseline\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      (&lt;2\u00b72%;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015),\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      increased by 350%, normalizing by 6\u00a0months after surgery (baseline: 0\u00b781\u00b1\u00a00\u00b719%; 6\u00a0months: 3\u00b718\u00a0\u00b1\u00a00\u00b779%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b702\n                      <jats:italic>vs<\/jats:italic>\n                      baseline; 12months: 3\u00b768\u00a0\u00b1\u00a01\u00b722%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00\u00b704\n                      <jats:italic>vs<\/jats:italic>\n                      baseline). Baseline calcium,\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      and 25\n                      <jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>\n                      levels did not differ between those with abnormal\n                      <jats:italic>vs<\/jats:italic>\n                      normal\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      , nor did these indices predict postoperative change in\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      is generally normal in patients with mild\n                      <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>\n                      and is unchanged 1\u00a0year after parathyroidectomy. Although\n                      <jats:styled-content style=\"fixed-case\">FMD<\/jats:styled-content>\n                      may normalize after surgery in patients with baseline abnormalities, data do not support using endothelial dysfunction as an indicator for parathyroidectomy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04485.x","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T08:57:14Z","timestamp":1341305834000},"page":"204-209","source":"Crossref","is-referenced-by-count":28,"title":["Endothelial function in mild primary hyperparathyroidism"],"prefix":"10.1111","volume":"78","author":[{"given":"A. L.","family":"Carrelli","sequence":"first","affiliation":[{"name":"Department of Medicine College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Di Tullio","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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