{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:31:29Z","timestamp":1763116289381},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T00:00:00Z","timestamp":1364169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Ghrelin and obestatin have apparent opposite orexigenic and anorexigenic effects, although the latter has not been firmly demonstrated in humans. So far, little data have been reported in relation to its potential association with metabolic syndrome (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>). The objective was to study obestatin concentrations in relation to nutritional parameters and eating behaviours in old women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>Prospective study; a total of 110 women (age: 76\u00b793\u00a0\u00b1\u00a06\u00b732) from the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>atar\u00f3 <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>geing <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy were included. Individuals were characterized by anthropometric variables, lipids, glucose, blood pressure, <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> components (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>dult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reatment <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>anel III criteria), anorexia and nutritional status by <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ini <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>utritional <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hort <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>orm (<jats:styled-content style=\"fixed-case\">MNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>) and re\u2010evaluated at 2\u2010year follow\u2010up. Obestatin was measured by <jats:styled-content style=\"fixed-case\">IRMA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>58\u00b72% of the subjects had <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>; at 2\u2010year follow\u2010up 24\u00b71% had a weight loss &gt;5%, 7\u00b72% &gt;10%, and 26\u00b74% changed their <jats:styled-content style=\"fixed-case\">MNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> score to risk of malnutrition category. Anorexia was present in 38\u00b74%. Obestatin levels were not related to either change of weight, <jats:styled-content style=\"fixed-case\">MNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> or anorexia, but a positive correlation was found with the absolute difference between basal and 2\u2010year waist circumference (<jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>) (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7429; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and relative difference between basal and 2\u2010year <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b7420; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001); both remained significant after adjusting for age and body mass index. When obestatin was divided into quartiles, a significant lineal trend was observed in relation to <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7049), absolute and relative difference between basal and 2\u2010year <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Obestatin was associated with glucose impairment (69\u00b70% in 4th quartile <jats:italic>vs<\/jats:italic> 47\u00b75% in 1st to 3rd, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7047; after adjustment, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7098) and <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> (77\u00b78% in 4th <jats:italic>vs<\/jats:italic> 51\u00b73% in 1st to 3rd, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017; after adjustment, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7046, <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2\u00b790 (1\u00b702\u20138\u00b725) 4th <jats:italic>vs<\/jats:italic> 1st to 3rd).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Obestatin is elevated in aged women bearing <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> but is otherwise not associated with other nutritional parameters, weight loss or anorexia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04489.x","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T05:29:18Z","timestamp":1341811758000},"page":"882-890","source":"Crossref","is-referenced-by-count":7,"title":["Obestatin does not modify weight and nutritional behaviour but is associated with metabolic syndrome in old women"],"prefix":"10.1111","volume":"78","author":[{"given":"Mireia","family":"Mora","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nutrition Hospital Cl\u00ednic i Universitari of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria L.","family":"Granada","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Hospital Universitari Germans Trias i Pujol Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Roca","sequence":"additional","affiliation":[{"name":"Department of 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