{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:56:36Z","timestamp":1757454996465},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transfusional iron overload primarily results in reticuloendothelial iron accumulation, which is considered to be less harmful than parenchymal iron accumulation. However, systematic and comprehensive data on endocrine function in transfusion\u2010associated haemochromatosis are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 25 aplastic anaemia patients (11 men and 14 women) diagnosed with transfusion\u2010associated haemochromatosis at a single institution. Pituitary function was determined with a combined pituitary function test. On a different day, a 75\u2010g oral glucose tolerance test was performed. The bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) of the lumbar spine and total hip was assessed with dual\u2010energy <jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>\u2010ray absorptiometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two (88%) of these 25 patients had at least one endocrine abnormality, and 12 had more than one abnormality. The most common pituitary hormonal deficiency involved the pituitary\u2013gonadal axis; 54% of the total subjects had hypogonadotropic hypogonadism. Two patients had an insufficient cortisol response to corticotrophin\u2010releasing hormone stimulation. No patient had a deficiency of growth hormone or thyroid\u2010stimulating hormone. Twelve (48%) had diabetes mellitus, and these patients tended to have higher concentrations of ferritin, alanine aminotransferase and \u03b3\u2010glutamyl transferase. Osteoporosis (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010score &lt;\u22122\u00b75 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) was observed in 48% of patients. The reduction in <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was more pronounced in the lumbar spine than in the total hip. The patients with osteoporosis were accompanied by hypogonadism, which predominantly affected the trabecular bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our observations suggest that endocrinopathies are common in transfusion\u2010associated haemochromatosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2265.2012.04495.x","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T18:25:21Z","timestamp":1342203921000},"page":"271-277","source":"Crossref","is-referenced-by-count":22,"title":["Endocrinopathies in transfusion\u2010associated iron overload"],"prefix":"10.1111","volume":"78","author":[{"given":"Mee Kyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Wook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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